AI Summary & Key Takeaways
AI InsightSerum levels of IL-6, IL-8, TNF-α, CRP, and HSP 70 were measured.Results: In patients with active disease, significantly higher mean serum levels of IL-6, IL-8, TNF-α, and CRP were found compared to patients with inactive disease or in controls (overall, P < 0.05).
📌 3 Key Takeaways
Abstract
Aim: The aim of this study was to elucidate serum levels of IL-6, IL-8, TNF-α, CRP, and HSP 70 in patients with active or inactive Behçet’s disease.Materials and methods: The study included 50 patients who met the International Study Group criteria for Behçet’s disease. Of these, 26 had active disease and 24 had inactive disease. The control group was comprised of 25 age- and sex- matched healthy participants. Serum levels of IL-6, IL-8, TNF-α, CRP, and HSP 70 were measured.Results: In patients with active disease, significantly higher mean serum levels of IL-6, IL-8, TNF-α, and CRP were found compared to patients with inactive disease or in controls (overall, P < 0.05). In patients with active disease, the mean serum level of HSP 70 was significantly higher than that of the control group (P = 0.02). In patients with inactive disease it was higher compared to the controls but with a significance level close to 0.05 (P = 0.044). However, HSP 70 levels did not differ significantly between patients with active disease and patients with inactive disease (P = 0.93).Conclusion: The results of our study suggest that serum IL-6, IL-8, TNF-α, and CRP levels are increased in patients with active Behçet’s disease. HSP 70 levels in both active and inactive disease groups were higher than in controls, though it was significant only in the active group. This suggests that HSP 70 has a role in the chronic nature of Behçet’s disease, with HSP 70 expression possibly not falling to normal levels in the inactive phase of the disease.
Özet
Amaç: Bu çalışmanın amacı, aktif ve inaktif Behçet hastalarında serum İL-6, İL-8, TNF-α, CRP ve HSP 70 düzeylerini araştırmaktır. Yöntem ve gereç: Çalışmaya Uluslararası Çalışma Grubunu kriterlerine gore Behçet hastalığı tanısı almış 50 hasta alındı. Bunların 26’sı aktif ve 24’ü inaktif hastalığa sahipti. Kontrol grubu yaş ve cinsiyet olarak çalışma grubuna benzeyen 25 sağlıklı bireyden oluşmaktaydı. Serum İL-6, İL-8, TNF-α, CRP ve HSP 70 düzeyleri ölçüldü. Bulgular:Ortalama serum İL-6, İL-8, TNF-α ve CRP düzeyleri aktif hastalığı olanlarda, inaktif hastalığı olanlar ve kontrol grubuna göre anlamlı şekilde yüksek bulundu ( hepsinde, P < 0,05). Ortalama serum HSP 70 düzeyi aktif hastalığı olanlarda kontrol grubuna göre anlamlı şekilde yüksek iken (P = 0,02), inaktif hastalığı olanlarda kontrol grubuna göre sınırda anlamlı yüksek bulundu (P = 0,044). Bununla birlikte aktif ve inaktif hastalar arasında anlamlı fark tespit edilmedi (P = 0,93). Sonuç: Aktif Behçet hastalarında serum serum İL-6, İL-8, TNF-α ve CRP düzeyleri artmaktadır. HSP 70 düzeyi aktif hastalarda belirgin olmak üzere hem aktif hem de inaktif hasta grubunda kontrol grubuna göre yüksek bulunmaktadır. Bu da, HSP 70’in Behçet hastalığının kronik seyrinde rol aldığını ve inaktif hastalık fazında HSP 70 düzeyleri normal değerlerine kadar yeterince düşmediğini göstermektedir.