Journals / Turkish Journal of Medical Sciences / 2012 / Cilt: 42 - Sayı: 3

Mesleki kükürt dioksit maruziyetine bağlı astım benzeri sendromunda yoğunlaşmış ekspirium havasında nitrik oksit düzeyinin artması

Increased nitrite levels in exhaled breath condensate in asthmalike syndrome induced by occupational sulfur dioxide exposure

Pages
425–431
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We concluded that nitrite levels in EBC are increased in the asthma-like syndrome induced by occupational SO2 exposure in an agricultural environment, suggesting the role of infl ammation in the syndrome; this first application of the EBC method may be suitable in other field studies in occupational medicine.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To investigate whether nitrite levels were abnormally high in expired breath condensate (EBC) from workers with asthma-like syndrome.
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Key Findings & Data:Materials and methods: We measured the nitrite levels in EBC from 48 volunteer workers, including 25 smokers, with asthma-like syndrome before and after SO2 exposure and compared these levels with those from 44 nonexposed control subjects, including 23 smokers.
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Conclusion & Impact:Conclusion: We concluded that nitrite levels in EBC are increased in the asthma-like syndrome induced by occupational SO2 exposure in an agricultural environment, suggesting the role of infl ammation in the syndrome; this first application of the EBC method may be suitable in other field studies in occupational medicine.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To investigate whether nitrite levels were abnormally high in expired breath condensate (EBC) from workers with asthma-like syndrome. Materials and methods: We measured the nitrite levels in EBC from 48 volunteer workers, including 25 smokers, with asthma-like syndrome before and after SO2 exposure and compared these levels with those from 44 nonexposed control subjects, including 23 smokers. Results: Baseline concentrations of nitrite in the workers before SO2 exposure were higher (19.31 ± 1.06 nmol/mL) than in the controls (13.08 ± 1.36 nmol/mL; P 0.05). Conclusion: We concluded that nitrite levels in EBC are increased in the asthma-like syndrome induced by occupational SO2 exposure in an agricultural environment, suggesting the role of infl ammation in the syndrome; this first application of the EBC method may be suitable in other field studies in occupational medicine.

Özet

Amaç: Bu çalışmanın amacı bu işçilerde yoğunlaşmış ekspirum havasında (YEH) nitrit seviyesinin artıp artmadığını araştırmaktır. Yöntem ve gereç: Çalışmaya 25i sigara içenlerden olmak üzere 48 gönüllü ABSu olan işçi ve benzer yaş ve cinsiyetten 23ü sigara içenlerden olmak üzere 45 sağlıklı gönüllü alındı. İşçilerin SO2 maruziyeti öncesi ve sonrasında elde edilen YEHde nitrit düzeyleri ölçüldü ve sağlıklı kişilerinki ile karşılaştırıldı. Bulgular: ABSli işçilerin YEHde ölçülen bazal nitrit düzeyleri (19,31 ± 1,06 nmol/mL) sağlıklı gönüllülerin nitrit düzeylerinden (13,08 ± 1,36 nmol/mL, P 0,05). Sonuç: Bu çalışmada tarım iş kolunda kayısı kükürtleme işlemi sırasında SO2 maruziyeti sonucu oluşan ABSli işçilerin YEH nitrit düzeylerinin arttığı gösterildi. Bu artış bu sendromun patogenezinde inflamasyonun olabileceğini düşündürmektedir. Bu çalışma tarım iş kolunda yapılan ilk çalışmadır ve bu yöntemin alan çalışmalarında uygun olabileceğini göstermektedir.

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Cite This Article

KILIÇ, T., SÖĞÜT, S., YILDIRIM, Z., KÖKSAL, N. (2022). Mesleki kükürt dioksit maruziyetine bağlı astım benzeri sendromunda yoğunlaşmış ekspirium havasında nitrik oksit düzeyinin artması. Turkish Journal of Medical Sciences, Cilt: 42 - Sayı: 3, 425–431. https://ajindex.com/articles/611209

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References (15)

  1. American Thoracic Society. Respiratory health hazards in agriculture. Am J Respir Crit Care Med 1998; 158: S1-S76
  2. Ong SG, Lam TH, Wong CM, Chow WK, Ma PL, Lam SK et al. Byssinosis and other respiratory problems in the cotton industry of Hong Kong. Am J Ind Med 1987; 12: 773-7
  3. Morris PO, Lenhart SW, Service WS. Respiratory symptoms and pulmonary function in chicken catchers in poultry confinement units. Am J Ind Med 1991; 19: 195-204
  4. Chan-Yeung M, Wong R, MacLean L, Tan F, Dorken E, Schulzer M et al. Epidemiologic health survey of grain elevator workers in British Columbia. Am Rev Respir Dis 1980; 121: 329-38
  5. Thelin A, Tegler O, Rylander R. Lung reactions during poultry handling related to dust and bacterial endotoxin levels. Eur J Respir Dis 1984; 65: 266-71
  6. Donham KJ, Zavala DC, Merchant J. Acute effects of the work environment on pulmonary functions of swine confi nement workers. Am J Ind Med 1984; 5: 367-75
  7. Donham KJ, Reynolds SJ, Whitten P, Merchant JA, Burmeister L, Popendorf WJ. Respiratory dysfunction in swine production facility workers in dose-response relationships of environmental exposure and pulmonary function. Am J Ind Med 1995; 27: 405-18
  8. Koksal N, Hasanoglu HC, Gokirmak M, Yildirim Z, Gultek A. Apricot sulfurization: an occupation that induces an asthmalike syndrome in agricultural environments. Am J Ind Med 2003; 43: 447-53
  9. Widdicombe JG. Reflex control of airways smooth muscle. Postgraduate Med J 1975; 51: 36-43
  10. Snashall PD, Baldwin C. Mechanisms of sulphur dioxide induced bronchoconstriction in normal and asthmatic man. Thorax 1982; 37: 118-23
  11. Sheppard D, Nadel JA, Boushey HA. Inhibition of sulfur dioxide-induced bronchoconstriction by disodium cromoglycate in asthmatic subjects. Am Rev Respir Dis 1981; 124: 257-9
  12. Peden DB. Mechanisms of pollution-induced airway disease: in vivo studies. Allergy 1997; 52: 37-44
  13. Fine JM, Gordon T, Sheppard D. The roles of pH and ionic species in sulfur dioxide- and sulfi te-induced bronchoconstriction. Am Rev Respir Dis 1987; 136: 1122-6
  14. Gokirmak M, Yildirim Z, Hasanoglu HC, Koksal N, Mehmet N. The role of oxidative stress in bronchoconstriction due to occupational sulfur dioxide exposure. Clin Chim Acta 2003; 331: 119-26
  15. Koksal N, Yildirim Z, Gokirmak M, Hasanoglu HC, Mehmet N, Avci H. The role of nitric oxide and cytokines in asthma-like syndrome induced by sulfur dioxide exposure in agricultural environment. Clin Chim Acta 2003; 336: 115-