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Journals / Turkish Journal of Medical Sciences / 2013 / Cilt: 43 - Sayı: 1

AEG-1 expression in invasive ductal and lobular breast cancers and its relationship with prognostic parameters

Handan ANKARALI
Mehmet YAŞAR
Murat OKTAY
Havva ERDEM
Ümran YILDIRIM
Ali Kemal UZUNLAR
Pages
93–98
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

AEG-1 could be a useful marker for the development of new treatments and resistant hormonal therapy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The astrocyte-elevated gene-1 (AEG-1, also known as metadherin) is associated with various aspects of tumour malignancy; however, little knowledge is available related to the role of AEG-1 in ductal and lobular carcinomas.
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Key Findings & Data:The aim of this study was to investigate the relationship of AEG-1 with the prognostic parameters in invasive ductal and lobular carcinomas.
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Conclusion & Impact:AEG-1 could be a useful marker for the development of new treatments and resistant hormonal therapy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Ductal carcinomas · lobular carcinomas · AEG-1

Abstract

The astrocyte-elevated gene-1 (AEG-1, also known as metadherin) is associated with various aspects of tumour malignancy; however, little knowledge is available related to the role of AEG-1 in ductal and lobular carcinomas. The aim of this study was to investigate the relationship of AEG-1 with the prognostic parameters in invasive ductal and lobular carcinomas. Materials and methods: This study was conducted on a total of 72 paraffin-embedded breast tumour samples. They consisted of 61 ductal and 11 lobular carcinomas. Breast tumour samples were stained for AEG-1. The prognostic parameters were compared with the results of AEG-1 stains. Results: We observed that more ductal carcinoma types than lobular carcinoma types resulted in high AEG-1 staining, whereas low AEG-1 staining occurred more in lobular carcinomas than in ductal carcinomas (P = 0.05). A significant negative correlation was also found between HER-2 (r = -0.30, P = 0.019) and AEG-1 (r = -0.804, P = 0.003) in lobular carcinomas. A significant relationship was found between increasing numbers of positive lymph nodes and AEG-1 in ductal carcinoma cases (P = 0.05). Conclusion: These results are consistent with previous reports of the role of AEG-1 in tumour progression. AEG-1 could be a useful marker for the development of new treatments and resistant hormonal therapy.

Özet

The astrocyte-elevated gene-1 (AEG-1, also known as metadherin) is associated with various aspects of tumour malignancy; however, little knowledge is available related to the role of AEG-1 in ductal and lobular carcinomas. The aim of this study was to investigate the relationship of AEG-1 with the prognostic parameters in invasive ductal and lobular carcinomas. Materials and methods: This study was conducted on a total of 72 paraffin-embedded breast tumour samples. They consisted of 61 ductal and 11 lobular carcinomas. Breast tumour samples were stained for AEG-1. The prognostic parameters were compared with the results of AEG-1 stains. Results: We observed that more ductal carcinoma types than lobular carcinoma types resulted in high AEG-1 staining, whereas low AEG-1 staining occurred more in lobular carcinomas than in ductal carcinomas (P = 0.05). A significant negative correlation was also found between HER-2 (r = -0.30, P = 0.019) and AEG-1 (r = -0.804, P = 0.003) in lobular carcinomas. A significant relationship was found between increasing numbers of positive lymph nodes and AEG-1 in ductal carcinoma cases (P = 0.05). Conclusion: These results are consistent with previous reports of the role of AEG-1 in tumour progression. AEG-1 could be a useful marker for the development of new treatments and resistant hormonal therapy.

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Cite This Article

ANKARALI, H., YAŞAR, M., OKTAY, M., ERDEM, H., YILDIRIM, Ü., UZUNLAR, A. K. (2022). AEG-1 expression in invasive ductal and lobular breast cancers and its relationship with prognostic parameters. Turkish Journal of Medical Sciences, Cilt: 43 - Sayı: 1, 93–98. https://ajindex.com/articles/611101

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