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Journals / Turkish Journal of Medical Sciences / 2016 / Cilt: 46 - Sayı: 6

New immunohistochemical markers in the differential diagnosis of nonsmall cell lung carcinoma

Ferda BİR
Arzu YAREN
Tamer EDİRNE
Duygu ÇELİKER
Binnaz Fatma EVYAPAN
Pages
1854–1861
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our data suggest that Napsin-A, NTRK-2, and Desmocollin-3 are useful markers in the differentiation of nonsmall cell lung cancer.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: The aim of this study was to investigate Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in the differential diagnosis and prognosis of nonsmall cell lung cancer.
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Key Findings & Data:Materials and methods: The expression of Napsin-A, NTRK-1, NTRK-2, and Desmoglein-3 was examined by immunohistochemistry in 50 squamous cell carcinomas and 50 adenocarcinomas.
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Conclusion & Impact:Conclusion: Our data suggest that Napsin-A, NTRK-2, and Desmocollin-3 are useful markers in the differentiation of nonsmall cell lung cancer.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: The aim of this study was to investigate Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in the differential diagnosis and prognosis of nonsmall cell lung cancer. Materials and methods: The expression of Napsin-A, NTRK-1, NTRK-2, and Desmoglein-3 was examined by immunohistochemistry in 50 squamous cell carcinomas and 50 adenocarcinomas. Desmocollin-3 was investigated in 29 squamous cell carcinoma and 29 adenocarcinoma cases. Associations between expression profiles of Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in lung cancers and clinicopathological variables were analyzed. Results: Napsin-A staining was statistically significant in detecting adenocarcinomas versus squamous cell carcinomas. The sensitivity of Napsin-A for adenocarcinomas was 96% and the specificity was 100%. NTRK-2 and Desmocollin-3 staining were statistically significant in detecting squamous cell carcinomas versus adenocarcinomas. Desmoglein-3, Napsin-A, and NTRK-2 had no effect on survival. Disease-free survival time was significantly shorter in cases that were moderately positive with NTRK-1. Conclusion: Our data suggest that Napsin-A, NTRK-2, and Desmocollin-3 are useful markers in the differentiation of nonsmall cell lung cancer.

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Cite This Article

BİR, F., YAREN, A., EDİRNE, T., ÇELİKER, D., EVYAPAN, B. F. (2022). New immunohistochemical markers in the differential diagnosis of nonsmall cell lung carcinoma. Turkish Journal of Medical Sciences, Cilt: 46 - Sayı: 6, 1854–1861. https://ajindex.com/articles/611080

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