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Journals / Turkish Journal of Medical Sciences / 2013 / Cilt: 43 - Sayı: 1

A comparison of tramadol, sufentanil, meperidine, and lidocaine in prevention of pain due to rocuronium injection

Mehtap HONCA
Tevfik HONCA
Uğur ÖZKAN
Belkız Berna KÜLAH
Nuray ERYILMAZ CAMGÖZ
Eyüp HORASANLI
Tarık PURTULOĞLU
Pages
79–83
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Lidocaine seemed to be the most effective analgesic drug for minimizing the pain due to rocuronium injection.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Alleviation of the pain resulting from injection of rocuronium during anesthesia is still an unsolved problem.
📊
Key Findings & Data:Materials and methods: This prospective randomized double-blind study included 200 patients with ASA I-II.
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Conclusion & Impact:Lidocaine seemed to be the most effective analgesic drug for minimizing the pain due to rocuronium injection.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Rocuronium · injection pain · opioids

Abstract

Alleviation of the pain resulting from injection of rocuronium during anesthesia is still an unsolved problem. We aimed to compare the analgesic effects of sufentanil, tramadol, meperidine, and lidocaine on the pain from injection of rocuronium. Materials and methods: This prospective randomized double-blind study included 200 patients with ASA I-II. After a tourniquet was applied to the forearm, patients received 50 mg of tramadol (group T), 10 µg of sufentanil (group S), 40 mg of meperidine (group M), or 30 mg of lidocaine (group L). The tourniquet was released after 20 s and rocuronium was injected over 10 to 15 s. The patients were asked whether the injection caused pain or not. Side effects were recorded. Results: The incidence of injection pain was highest in group T. Severe pain was most frequently encountered in group S. Lidocaine was the most effective analgesic in alleviating the injection pain while sufentanil was the least effective drug (P < 0.05). Erythema was the common side effect at the injection site in group M and arrhythmia was observed in group T. Conclusion: The analgesic effect of meperidine was not significantly superior to that of the other drugs. Lidocaine seemed to be the most effective analgesic drug for minimizing the pain due to rocuronium injection.

Özet

Alleviation of the pain resulting from injection of rocuronium during anesthesia is still an unsolved problem. We aimed to compare the analgesic effects of sufentanil, tramadol, meperidine, and lidocaine on the pain from injection of rocuronium. Materials and methods: This prospective randomized double-blind study included 200 patients with ASA I-II. After a tourniquet was applied to the forearm, patients received 50 mg of tramadol (group T), 10 µg of sufentanil (group S), 40 mg of meperidine (group M), or 30 mg of lidocaine (group L). The tourniquet was released after 20 s and rocuronium was injected over 10 to 15 s. The patients were asked whether the injection caused pain or not. Side effects were recorded. Results: The incidence of injection pain was highest in group T. Severe pain was most frequently encountered in group S. Lidocaine was the most effective analgesic in alleviating the injection pain while sufentanil was the least effective drug (P < 0.05). Erythema was the common side effect at the injection site in group M and arrhythmia was observed in group T. Conclusion: The analgesic effect of meperidine was not significantly superior to that of the other drugs. Lidocaine seemed to be the most effective analgesic drug for minimizing the pain due to rocuronium injection.

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Cite This Article

HONCA, M., HONCA, T., ÖZKAN, U., KÜLAH, B. B., CAMGÖZ, N. E., HORASANLI, E., PURTULOĞLU, T. (2022). A comparison of tramadol, sufentanil, meperidine, and lidocaine in prevention of pain due to rocuronium injection. Turkish Journal of Medical Sciences, Cilt: 43 - Sayı: 1, 79–83. https://ajindex.com/articles/611061

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References (12)

  1. Mayer M, Doenicke A, Peter K. Onset and recovery of rocuronium (Org 9426) and vecuronium under enflurane anaesthesia. Br J Anaesth 1992; 69: 511–2.
  2. Bartkowski RR, Witkowski TA, Azad S, Lessin J, Marr A. Rocuronium onset of action: a comparison with atracurium and vecuronium. Anesth Analg 1993; 77: 574–8.
  3. Steegers MA, Robertson EN. Pain on injection of rocuronium bromide. Anesth Analg 1996; 83: 203. Moorthy SS, Dierdorf SF. Pain on injection of rocuronium bromide. Anesth Analg 1995; 80: 1067. Joshi GP, Whitten CW. Pain on injection of rocuronium bromide. Anesth Analg 1997; 8: 228. Shevchenko Y, Jocson JC, McRae VA, Stayer SA, Schwartz RE, Rehman M et al. The use of lidocaine for preventing the withdrawal associated with the injection of rocuronium in children and adolescents. Anesth Analg 1999; 88: 746–8.
  4. King SY, Davis FM, Wells JE, Murchison DJ, Pryor PJ. Lidocaine for the prevention of pain due to injection of propofol. Anesth Analg 1992; 74: 246–9.
  5. Kobayashi Y, Tsuchida A, Kamada Y, Seki S, Ichimiya T, Namiki A. Effects of speed of injection on anesthesia induction with propofol and fentanyl. Masui 1999; 48: 847–51.
  6. Vickers MD, O’Flaherty D, Szekely SM, Read M, Yoshizumi J. Tramadol: pain relief by an opioid without depression of respiration. Anaesthesia 1992; 47: 291–6.
  7. Pang WW, Mok MS, Chang DP, Yang TF, Lin CH, Huang MH. Intradermal injection of tramadol has local anesthetic effect: a comparison with lidocaine. Acta Anaesthesiol Sin 1998; 36: 133– Tsai YC, Chang PJ, Jou IM. Direct tramadol application on sciatic nerve inhibits spinal somatosensory evoked potentials in rats. Anesth Analg 2001; 92: 1547–51.
  8. Pang WW, Mok MS, Huang S, Hwang MH. The analgesic effect of fentanyl, morphine, meperidine, and lidocaine in the peripheral veins: a comparative study. Anesth Analg 1998; 86: 382– Heier T, Caldwell JE. Rapid tracheal intubation with large dose rocuronium: a probability-based approach. Anesth Analg 2000; 90: 175–9.
  9. Klement W, Arndt JO. Pain on I.V. injection of some anaesthetic agent is evoked by the unphysiological osmolality or pH of their formulations. Br J Anaesth 1991; 66: 189–95.
  10. Cheong KF, Wong WH. Pain on injection of rocuronium: influence of two doses of lidocaine pretreatment. Br J Anaesth 2000; 84: 106–7.
  11. Turan A, Memis D, Karamanlioglu B, Sut N, Pamukcu Z. The prevention of pain from injection of rocuronium by magnesium sulphate, lidocaine, sodium bicarbonate and alfentanil. Anaesth Intensive Care 2003; 31: 277–81.
  12. Chiarella AB, Jolly DT,