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Journals / Turkish Journal of Medical Sciences / 2016 / Cilt: 46 - Sayı: 3

Correlation between HFE gene polymorphisms and increased risk of coronary artery disease among patients with type 2 diabetes in Iran

Shirin LOTFIPANAH
Marzieh SAREMI
Saber IMANI
Junjiang FU
Tianyu ZHANG
Leila SAREMI
Pages
590–596
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our results revealed a significant correlation between C282Y and H63D mutations and the development of CAD in T2D patients

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: Diabetes mellitus is a risk factor for cardiovascular diseases (CVDs), which are among the major causes of deaths in type 2 diabetes (T2D).
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Key Findings & Data:The purpose of the present study was to determine the association of C282Y and H63D mutations in the HFE gene with increased risk of coronary artery disease (CAD) in T2D patients.
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Conclusion & Impact:Conclusion: Our results revealed a significant correlation between C282Y and H63D mutations and the development of CAD in T2D patients
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: Diabetes mellitus is a risk factor for cardiovascular diseases (CVDs), which are among the major causes of deaths in type 2 diabetes (T2D). The purpose of the present study was to determine the association of C282Y and H63D mutations in the HFE gene with increased risk of coronary artery disease (CAD) in T2D patients. Materials and methods: Two hundred and ninety individuals were divided into two groups: a case group and a control group. Genomic DNA of peripheral venous blood cells was extracted and the HFE gene mutations were analyzed using the PCR RFLP technique. Results: Data analysis revealed a significant difference between the allele frequencies of H63D and C282Y mutations between the case group and the controls (P 0.05). Using a logistic regression model, BMI, FBS, HDL, and total cholesterol levels were significantly different with independent predictors of CVD (P < 0.05). Conclusion: Our results revealed a significant correlation between C282Y and H63D mutations and the development of CAD in T2D patients

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Cite This Article

LOTFIPANAH, S., SAREMI, M., IMANI, S., FU, J., ZHANG, T., SAREMI, L. (2022). Correlation between HFE gene polymorphisms and increased risk of coronary artery disease among patients with type 2 diabetes in Iran. Turkish Journal of Medical Sciences, Cilt: 46 - Sayı: 3, 590–596. https://ajindex.com/articles/610757

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