Journals / Turkish Journal of Medical Sciences / 2016 / Cilt: 46 - Sayı: 6

Cryptogenic organizing pneumonia: clinical and radiological features, treatment outcomes of 17 patients, and review of the literature

Pages
1712–1718
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Corticosteroids are a good treatment option in general, but relapse may occur.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: We evaluated patients with cryptogenic organizing pneumonia (COP) who attended our clinic.
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Key Findings & Data:Materials and methods: We retrospectively investigated the clinical and radiological findings, diagnostic methods, treatment, and follow-up outcomes of 17 patients who had been histopathologically diagnosed with COP.
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Conclusion & Impact:Corticosteroids are a good treatment option in general, but relapse may occur.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: We evaluated patients with cryptogenic organizing pneumonia (COP) who attended our clinic. Materials and methods: We retrospectively investigated the clinical and radiological findings, diagnostic methods, treatment, and follow-up outcomes of 17 patients who had been histopathologically diagnosed with COP. Results: The mean age of the patients was 49.8 ± 10.4 years. The most common symptom was cough (n = 15; 88.2%) and the most common radiological finding (n = 10) was consolidation in the inferior lobes on thoracic computed tomography. The diagnosis of COP was made by open lung biopsy in 11 (64.7%) patients, transbronchial biopsy in 5 (29.4%), and video-assisted thoracoscopic surgery biopsy in 1 (5.9%). The mean follow-up period was 28.7 ± 25.0 (range: 3 85) months. Twelve patients received oral corticosteroid therapy and seven of them improved without any fibrotic changes. One patient refused treatment; a chest radiography of that patient was found to be normal at the end of the 20-month follow-up period. Three patients received no other therapy, as the lesion had been completely excised. Conclusion: Common symptoms included cough and dyspnea, while the main radiological presentation of COP was consolidation. Corticosteroids are a good treatment option in general, but relapse may occur.

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Cite This Article

YURT, S., KILIÇ, L., ÇAMSARI, G., ÖZKAN, G. Z., NİKSARLIOĞLU, E. Y., BAKAN, N. D. (2022). Cryptogenic organizing pneumonia: clinical and radiological features, treatment outcomes of 17 patients, and review of the literature. Turkish Journal of Medical Sciences, Cilt: 46 - Sayı: 6, 1712–1718. https://ajindex.com/articles/610700

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References (16)

  1. Colby TV. Pathologic aspects of bronchiolitis obliterans organizing pneumonia. Chest 1992; 102: 38S-43S
  2. Travis WD, Costabel U, Hansell DM, King TE Jr, Lynch DA, Nicholson AG, Ryerson CJ, Ryu JH, Selman M, Wells AU et al. An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2013; 188: 733-748
  3. Oymak FS, Demirbas HM, Mavili E, Akgun H, Gulmez I, Demir R, Ozesmi M. Bronchiolitis obliterans organizing pneumonia. Respiration 2005; 72: 254-262
  4. Kıter G, Yuncu G, Bir F, Karabulut N, Özkurt S, Evyapan F. Cryptogenic organizing pneumonia: two cases and an update. Toraks Dergisi 2008; 9: 43-48 (in Turkish with English abstract)
  5. Kivanc T, Ekici ZU, Dogan CR, Kiyici H, Eyuboglu FO. Cryptogenic organising pneumonia: four cases with different radiological manifestations. Eurasian J Pulmonol 2011; 13: 114-120
  6. Nishino M, Mathai SK, Schoenfeld D, Digumarthy SR, Kradin RL. Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. Hum Pathol 2014; 45: 342- 351
  7. Cottin V, Cordier JF. Cryptogenic organizing pneumonia. Semin Respir Crit Care Med 2012; 33: 462-475
  8. Cordier JF, Costabel U, du Bois R. Cryptogenic organizing pneumonia. Orphanet Encyclopedia, October 2004. Available online at http://www.orpha.net/consor/cgi-bin/OC_Exp. php?Expert=1302
  9. Wells AU. Cryptogenic organizing pneumonia. Semin in Respir Crit Care Med 2001; 22: 449-459
  10. Cordier JF. Cryptogenic organizing pneumonia. Eur Respir J 2006; 28: 422-446
  11. Lazor R, Vandevenne A, Pelletier A, Leclerc P, Court-Fortune I, Codier JF. Cryptogenic organizing pneumonia: characteristics of relapses in a series of 48 patients. Am J Respir Crit Care Med 2000; 162: 571-577
  12. King TE Jr, Mortenson RL. Cryptogenic and organizing pneumonitis. The North American experience. Chest 1992; 102: 8S-13S
  13. Drakopanagiotakis F, Paschalaki K, Abu-Hijleh M, Aswad B, Karagianidis N, Kastanakis E, Braman SS, Polychronopoulos V. Cryptogenic and organizing pneumonia. Chest 2011; 139: 893-900
  14. Codier JF, Loire R, Brune J. Idiopathic BOOP: definition of characteristic clinical profiles in a series of 16 patients. Chest 1989; 96: 999-1004
  15. Cordier JF. Cryptogenic organizing pneumonitis. Bronchiolitis obliterans organizing pneumonia. Clin Chest Med 1993; 14: 677-692
  16. Yoo JW, Song JW, Jang SJ, Lee CK, Kim MY, Lee HK