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Journals / Turkish Journal of Medical Sciences / 2016 / Cilt: 46 - Sayı: 4

Effectiveness of a single versus repeated administration of trimetazidine in the protection against warm ischemia/reperfusion injury of rat liver

Asma MAHFOUDH BOUSSAID
Rabi SELMI
Kaouther HADJ AYED
Mohamed Amine ZAOUALI
Hassen BEN ABDENNEBI
Mohamed BEJAOUI
Pages
1258–1264
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These effects implicate AMPK and eNOS activation.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: The aim of this study was to compare the effects of single and repeated trimetazidine (TMZ) administration against warm hepatic ischemia/reperfusion (I/R) injury and to explore the possible mechanisms affected by TMZ.
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Key Findings & Data:Materials and methods: Wistar rats were divided into 4 groups (n = 6).
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Conclusion & Impact:These effects implicate AMPK and eNOS activation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: The aim of this study was to compare the effects of single and repeated trimetazidine (TMZ) administration against warm hepatic ischemia/reperfusion (I/R) injury and to explore the possible mechanisms affected by TMZ. Materials and methods: Wistar rats were divided into 4 groups (n = 6). Sham: rats were subjected to dissection. I/R: rats were subjected to 60 min of partial hepatic ischemia followed by 24 h of reperfusion. TMZ1: Same as I/R group but rats were pretreated with a single dose of TMZ (10 mg/kg, intraperitoneal injection) 30 min before warm ischemia. TMZ3: Same as I/R but rats were treated with 10 mg/ kg TMZ for 3 successive days. Results: TMZ treatment decreased liver injury, lipid peroxidation, and apoptosis. The repeated administration of TMZ conferred more protection than the single dose treatment concerning all studied parameters. In parallel, we noted a significant increase in phosphorylated adenosine monophosphate activated protein kinase (p-AMPK) and endothelial nitric oxide synthase (eNOS) levels in TMZ3 as compared to TMZ1. Conclusion: Repeated administration of TMZ for 3 days was more efficient than a single dose of TMZ in protecting the liver against I/R induced apoptosis and lipid peroxidation. These effects implicate AMPK and eNOS activation.

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Cite This Article

BOUSSAID, A. M., SELMI, R., AYED, K. H., ZAOUALI, M. A., ABDENNEBI, H. B., BEJAOUI, M. (2022). Effectiveness of a single versus repeated administration of trimetazidine in the protection against warm ischemia/reperfusion injury of rat liver. Turkish Journal of Medical Sciences, Cilt: 46 - Sayı: 4, 1258–1264. https://ajindex.com/articles/610692

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