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Journals / Turkish Journal of Medical Sciences / 2017 / Cilt: 47 - Sayı: 2

Alpha-1 Antitrypsin Levels and Polymorphisms in Interstitial Lung Diseases

Oya KAYACAN
Halil Gürhan KARABULUT
Demet KARNAK
Nalan DEMİR
Özlem ERÇEN DİKEN
Pages
476–482
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: The mean alpha-1 antitrypsin level in idiopathic interstitial pneumonia patients was 1.67 ± 0.33 g/L, and it was 1.54 ± 0.37 g/L in patients with nonidiopathic interstitial pneumonia (P = 0.13).

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: Alpha-1 antitrypsin deficiency may be a potential predisposing factor for interstitial lung fibrosis.
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Key Findings & Data:We investigated alpha-1 antitrypsin levels and its polymorphisms in patients with interstitial lung disease.
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Conclusion & Impact:Results: The mean alpha-1 antitrypsin level in idiopathic interstitial pneumonia patients was 1.67 ± 0.33 g/L, and it was 1.54 ± 0.37 g/L in patients with nonidiopathic interstitial pneumonia (P = 0.13).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: Alpha-1 antitrypsin deficiency may be a potential predisposing factor for interstitial lung fibrosis. We investigated alpha-1 antitrypsin levels and its polymorphisms in patients with interstitial lung disease. Materials and methods: A total of 103 interstitial lung disease patients were compared. Results: The mean alpha-1 antitrypsin level in idiopathic interstitial pneumonia patients was 1.67 ± 0.33 g/L, and it was 1.54 ± 0.37 g/L in patients with nonidiopathic interstitial pneumonia (P = 0.13). Low

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Cite This Article

KAYACAN, O., KARABULUT, H. G., KARNAK, D., DEMİR, N., DİKEN, Ö. E. (2022). Alpha-1 Antitrypsin Levels and Polymorphisms in Interstitial Lung Diseases. Turkish Journal of Medical Sciences, Cilt: 47 - Sayı: 2, 476–482. https://ajindex.com/articles/610537

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References (13)

  1. Mulgrew AT, Taggart CC, McElvaney NG. Alpha-1-antitrypsin deficiency: current concepts. Lung 2007; 185: 191-201
  2. Pham C. Neutrophil serine proteases fine-tune the inflammatory response. Int J Biochem Cell Biol 2008; 40: 1317- 1333
  3. Chua F, Laurent G. Neutrophil elastase. Mediator of extracellular matrix destruction and accumulation. Proc Am Thorac Soc 2006; 3: 424-427
  4. Knoell DL, Ralston DR, Coulter KR, Wewers MD. Alpha 1-antitrypsin and protease complexation is induced by lipopolysaccharide, interleukin-1β, and tumor necrosis factor-α in monocytes. Am J Respir Crit Care Med 1998; 157: 246-255
  5. Steiner SJ, Gupta SK, Croffie JM, Fitzgerald JF. Serum levels of α1-antitrypsin predict phenotypic expression of the α1- antitrypsin gene. Dig Dis Sci 2003; 48: 1793-1796
  6. Hutchison DC. Epidemiology of alpha 1-protease inhibitor deficiency. Eur Respir J 1990; 9: 29-34. 7. de Serres FJ. Worldwide racial and ethnic distribution of α1- antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys. Chest 2002; 122: 1818-1829
  7. Simsek H, Pinar A, Altinbas A, Alp A, Balaban YH, Buyukasik Y, Ozcebe O, Hascelik G, Gedikoglu G, Tatar G. Cutoff level to detect heterozygous alpha 1 antitrypsin deficiency in Turkish population. J Clin Lab Anal 2011; 25: 296-299
  8. Barnes TC, Cross A, Anderson ME, Edwards SW, Moots RJ. Relative α1-anti-trypsin deficiency in systemic sclerosis. Rheumatology (Oxford) 2011; 50: 1373-1378
  9. Travis WD, Costabel U, Hansell DM, King TE Jr, Lynch DA, Nicholson AG, Ryerson CJ, Ryu JH, Selman M, Wells AU et al. An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2013; 188: 733-748
  10. Cichy J, Potempa J, Travis J. Biosynthesis of α1-proteinase inhibitor by human lung-derived epithelial cells. J Biol Chem 1997; 272: 8250-8255
  11. Boutten A, Venembre P, Seta N, Hamelin J, Aubier M, Durand G, Dehoux MS. Oncostatin M is a potent stimulator of α1- antitrypsin secretion in lung epithelial cells: modulation by transforming growth factor-beta and interferon-gamma. Am J Respir Cell Mol Biol 1998; 18: 511-520
  12. Kalsheker N, Morley S, Morgan K. Gene regulation of the serine proteinase inhibitors α1-antitrypsin and α1-antichymotrypsin. Biochem Soc Trans 2002; 30: 93-98
  13. Knoell DL, Ralston DR, Coulter KR, Wewers MD. Alpha 1-antitrypsin and protease comple