The histopathological and stereological assessment of the effect of topically administered leptin on cerebral vasospasm in an experimental subarachnoid hemorrhage model

Conclusion: In accordance with the results, the topical administration of leptin can be used in the prevention of vasospasm, especially in unconscious patients with subarachnoid hemorrhage.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: Cerebral vasospasm is a term that refers to prolonged, slowly progressing but reversible pathological narrowing of cerebral arteries occurring several days after subarachnoid hemorrhage (SAH), usually accompanied by a decrease in perfusion distal to the affected artery.

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Key Findings & Data:Results: When mean serum leptin levels of the groups were compared, statistically significant differences were observed between the control and topical leptin-treated groups in favor of the treated groups with respect to serum leptin levels (P < 0.05).

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Conclusion & Impact:Conclusion: In accordance with the results, the topical administration of leptin can be used in the prevention of vasospasm, especially in unconscious patients with subarachnoid hemorrhage.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Background/aim: Cerebral vasospasm is a term that refers to prolonged, slowly progressing but reversible pathological narrowing of cerebral arteries occurring several days after subarachnoid hemorrhage (SAH), usually accompanied by a decrease in perfusion distal to the affected artery. Leptin is an endogenous polypeptide hormone that can be carried freely and bound to protein in the blood. Materials and methods: We investigated the superiority of topical application of leptin that may make a contribution to the development of new treatment modalities for unconscious patients in brain injury intensive care units and its preventive effect, which is considered to have multifactorial pathogenesis on cerebral vasospasm occurring after SAH via stereological studies of the basilar artery. Results: When mean serum leptin levels of the groups were compared, statistically significant differences were observed between the control and topical leptin-treated groups in favor of the treated groups with respect to serum leptin levels (P < 0.05). In the topical leptin-applied group, a significant difference in favor of vasodilatation was observed in the measurements of the basilar artery luminal area (P < 0.05). Conclusion: In accordance with the results, the topical administration of leptin can be used in the prevention of vasospasm, especially in unconscious patients with subarachnoid hemorrhage.

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Cite This Article

DENİZ, Ö. G., ÖNGER, M. E., AYDIN, K., MARANGOZ, A. H., ÇOKLUK, C., AKSOY, A., KAPLAN, S., KURUOĞLU, E., DEMİREL, C. (2022). The histopathological and stereological assessment of the effect of topically administered leptin on cerebral vasospasm in an experimental subarachnoid hemorrhage model. Turkish Journal of Medical Sciences, Cilt: 47 - Sayı: 5, 1602–1609. https://ajindex.com/articles/610516

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References (14)

Ingall T, Asplund K, Mahonen M, Bonita R. A multinational comparison of subarachnoid hemorrhage epidemiology in the WHO MONICA stroke study. Stroke 2000; 31: 1054-1061
Lanzino G, Kassell NF, Germanson TP, Kongable GL, Truskowski LL, Torner JC, Jane JA. Age and outcome after aneurysmal subarachnoid hemorrhage: why do older patients fare worse? J Neurosurg 1996; 85: 410-418
Vinall PE, Maislin G, Michele JJ, Deitch C, Simeone FA. Seasonal and latitudinal occurrence of cerebral vasospasm and subarachnoid hemorrhage in the northern hemisphere. Epidemiology 1994; 5: 302-308
Weir B. Aneurysms Affecting the Nervous System. Baltimore, MD, USA: Williams & Wilkins; 1994
Bromberg JE, Rinkel GJ, Algra A, Greebe P, van Duyn CM, Hasan D, Limburg M, ter Berg HW, Wijdicks EF, van Gijn J. Subarachnoid haemorrhage in first and second degree relatives of patients with subarachnoid haemorrhage. BMJ 1995; 311: 288-289
De Braekeleer M, Perusse L, Cantin L, Bouchard JM, Mathieu J. A study of inbreeding and kinship in intracranial aneurysms in the Saguenay Lac-Saint-Jean region (Quebec, Canada). Ann Hum Genet 1996; 60: 99-104
Gaist D, Vaeth M, Tsiropoulos I, Christensen K, Corder E, Olsen J, Sørensen HT. Risk of subarachnoid haemorrhage in first degree relatives of patients with subarachnoid haemorrhage: follow up study based on national registries in Denmark. BMJ 2000; 320: 141-145
Mayberg MR. Cerebral vasospasm. Neurosurg Clin N Am 1998; 9: 615-627
Samson WK, Murphy TC, Robison D, Vargas T, Tau E, Chang JK. A 35 amino acid fragment of leptin inhibits feeding in the rat. Endocrinology 1996; 137: 5182-5185
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432
Avraham Y, Davidi N, Lassri V, Vorobiev L, Kabesa M, Dayan M, Chernoguz D, Berry E, Leker RR. Leptin induces neuroprotection neurogenesis and angiogenesis after stroke. Curr Neurovasc Res 2011; 8: 313-322
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-295
Eikelis N, Wiesner G, Lambert G, Esler M. Brain leptin resistance in human obesity revisited. Regul Pept 2007; 139: 45-51
Fruhbeck G. Pivotal role of nitric oxide in the control of blood pressure after leptin administration. Diabetes 1