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Journals / Turkish Journal of Medical Sciences / 2017 / Cilt: 47 - Sayı: 6

Biomarker and shear stress in secondary pediatric pulmonary hypertension

Erman ÇAKAL
Muhammed KIZILGÜL
Mustafa ÖZBEK
Bekir UÇAN
Mustafa ŞAHİN
Pages
1854–1860
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The single nucleotide gene polymorphism COX-2-8473T>C might contribute to genetic susceptibility to differentiated thyroid cancer in the Turkish population.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: The most common thyroid malignancies are papillary and follicular thyroid carcinomas.
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Key Findings & Data:They account for approximately 85% 90% of all thyroid cancers.
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Conclusion & Impact:Conclusion: The single nucleotide gene polymorphism COX-2-8473T>C might contribute to genetic susceptibility to differentiated thyroid cancer in the Turkish population.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: The most common thyroid malignancies are papillary and follicular thyroid carcinomas. They account for approximately 85% 90% of all thyroid cancers. Recent studies have reported the relevance of cyclooxygenase-2 (COX-2) gene polymorphism in human carcinogenesis. The aim of this study was to investigate the relationship between thyroid carcinoma and COX2 gene polymorphism in the Turkish population. Materials and methods: We included a total of 96 differentiated thyroid cancer patients (mean age: 46.9 ± 10.3 years; 14 males, 82 females) and 83 healthy control subjects (mean age: 46.0 ± 10.6 years; 39 males, 44 females). The frequency of -765G>C, -8473T>C, and 1195A>G gene polymorphisms in the COX-2 promoter region was investigated in thyroid cancer patients and the control group using the high-resolution melting method. Results: COX-2-765G>C and COX-2-1195A>G gene polymorphisms were similar between thyroid cancer patients and the control group. There was a statistically significant difference between COX-2-8473T>C gene polymorphism in the thyroid cancer group and the control group (P = 0.012). Conclusion: The single nucleotide gene polymorphism COX-2-8473T>C might contribute to genetic susceptibility to differentiated thyroid cancer in the Turkish population.

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Cite This Article

ÇAKAL, E., KIZILGÜL, M., ÖZBEK, M., UÇAN, B., ŞAHİN, M. (2022). Biomarker and shear stress in secondary pediatric pulmonary hypertension. Turkish Journal of Medical Sciences, Cilt: 47 - Sayı: 6, 1854–1860. https://ajindex.com/articles/610504

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