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Journals / Turkish Journal of Medical Sciences / 2017 / Cilt: 47 - Sayı: 4

Chemokine CXCR-4 and cyclooxygenase-2 in the pathogenesis of pterygium

Eyyüp KARAHAN
Sülen SARIOĞLU
Hakan YILDIRIM
Gönen BAŞER
Oya Nermin SİVRİKOZ
Emine ŞEKER ÜN
Pages
1061–1066
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: CXCR-4 and COX-2 may play important roles in the pathogenesis of pterygium.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: This study aimed to investigate the expression of chemokine receptor 4 (CXCR-4) and cyclooxygenase-2 (COX-2) in the epithelium and stroma of pterygium tissue in comparison with healthy conjunctiva.
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Key Findings & Data:Materials and methods: The expression of CXCR4 and COX-2 was investigated by immunohistochemistry in the epithelium and stroma of the pterygium tissue of 29 eyes and compared with healthy conjunctival tissues.
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Conclusion & Impact:Conclusion: CXCR-4 and COX-2 may play important roles in the pathogenesis of pterygium.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: This study aimed to investigate the expression of chemokine receptor 4 (CXCR-4) and cyclooxygenase-2 (COX-2) in the epithelium and stroma of pterygium tissue in comparison with healthy conjunctiva. Materials and methods: The expression of CXCR4 and COX-2 was investigated by immunohistochemistry in the epithelium and stroma of the pterygium tissue of 29 eyes and compared with healthy conjunctival tissues. The correlation between CXCR4 and COX-2 expression as well as the correlation of these markers with the area of pterygium were evaluated statistically. Results: COX-2 staining scores were 1.75 ± 0.63 in the epithelium and 1.20 ± 0.62 in the stroma of the pterygium tissue. Mean CXCR-4 staining in the epithelium was 0.069 ± 0.37, whereas it was 5.0 ± 2.84 cells in the stroma. There was almost no staining of COX-2 and CXCR4 in the control samples. There was a strong positive correlation between the expression of CXCR-4 and COX-2 in the stroma of the pterygium. Conclusion: CXCR-4 and COX-2 may play important roles in the pathogenesis of pterygium.

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Cite This Article

KARAHAN, E., SARIOĞLU, S., YILDIRIM, H., BAŞER, G., SİVRİKOZ, O. N., ÜN, E. Ş. (2022). Chemokine CXCR-4 and cyclooxygenase-2 in the pathogenesis of pterygium. Turkish Journal of Medical Sciences, Cilt: 47 - Sayı: 4, 1061–1066. https://ajindex.com/articles/610404

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References (14)

  1. Coroneo MT, Giralomo N, Wakefield D. The pathogenesis of pterygia. Curr Opin Ophthalmol 2009; 10: 282-288
  2. Karagece YU, Seckin S. The expression of p53 and COX-2 in basal cell carcinoma, squamous cell carcinoma and actinic keratosis cases. Turkish Journal of Pathology 2012; 28: 119- 127
  3. Tsai YY, Chang CC, Chiang CC, Yeh KT, Chen PL, Chang CH, Chou MC, Lee H, Cheng YW. HPV infection and p53 inactivation in pterygium. Mol Vis 2009; 15: 1092-1097
  4. Hirst LW, Axelsen RA, Schwab I. Pterygium and associated ocular surface squamous neoplasia. Arch Ophthalmol 2009; 127: 31-32
  5. Chui J, Coroneo MT, Tat LT, Crouch R, Wakefield D, Di Girolamo N. Ophthalmic pterygium: a stem cell disorder with premalignant features. Am J Pathol 2011; 178: 817-827
  6. Chen GS, Yu HS, Lan CC, Chow KC, Lin TY, Kok LF, Lu MP, Liu CH, Wu MT. CXC chemokine receptor CXCR4 expression enhances tumorigenesis and angiogenesis of basal cell carcinoma. Br J Dermatol 2006; 154: 910-918
  7. Chu CY, Cha ST, Lin WC, Lu PH, Tan CT, Chang CC, Lin BR, Jee SH, Kuo ML. Stromal cell-derived factor-1α (SDF1α/ CXCL12)-enhanced angiogenesis of human basal cell carcinoma cells involves ERK1/2-NF-κB/interleukin-6 pathway. Carcinogenesis 2009; 30: 205-213
  8. Wald O, Shapira OM, Izhar U. CXCR4/CXCL12 axis in non small cell lung cancer (NSCLC) pathologic roles and therapeutic potential. Theranostics 2013; 3: 26-33
  9. Mukherjee D, Zhao J. The role of chemokine receptor CXCR4 in breast cancer metastasis. Am J Cancer Res 2013; 3: 46-55
  10. Toyozawa S, Kaminaka C, Furukawa F, Nakamura Y, Matsunaka H, Yamamoto Y. Chemokine receptor CXCR4 is a novel marker for the progression of cutaneous malignant melanomas. Acta Histochem Cytochem 2012; 45: 293-299
  11. Sciaccaluga M, D’Alessandro G, Pagani F, Ferrara G, Lopez N, Warr T, Gorello P, Porzia A, Mainiero F, Santoro A et al. Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration. PLoS One 2013; 8: e73426
  12. Ohira S, Sasaki M, Harada K, Sato Y, Zen Y, Isse K, Kozaka K, Ishikawa A, Oda K, Nimura Y et al. Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma. Am J Pathol 2006; 168: 1155-1168
  13. Shirahama T, Sakakura C. Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder. Clin Cancer Res 2001; 7: 558-561
  14. Fosslien E. Molecular pat