Predictors of mortality in cancer patients who need intensive care unit support: a two center cohort study

One-year survival was found to be significantly shorterin females than males (9 days vs. 12 days) in patients with lung cancer.Conclusion: Mortality rates of cancer patients who need ICU support are higher than overall ICU mortality.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: Cancer patients frequently need intensive care support due to respiratory failure.

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Key Findings & Data:We aimed to evaluate the predictorsof mortality in cancer patients who were admitted to the intensive care unit (ICU).Materials and methods: This study was performed in the ICUs of two centers between 1 January 2008 and 31 December 2015.Demographic data, cancer type, causes of respiratory failure, comorbidities, APACHE II scores, treatments, and mortality rates wererecorded.Results: A total number of 583 cancer patients (477 males) were enrolled from the two centers.

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Conclusion & Impact:One-year survival was found to be significantly shorterin females than males (9 days vs. 12 days) in patients with lung cancer.Conclusion: Mortality rates of cancer patients who need ICU support are higher than overall ICU mortality.

🔬Design:Research Article

📍Scope:2008 Verileri

⚙️Variables:Domain Parameters

Abstract

Background/aim: Cancer patients frequently need intensive care support due to respiratory failure. We aimed to evaluate the predictorsof mortality in cancer patients who were admitted to the intensive care unit (ICU).Materials and methods: This study was performed in the ICUs of two centers between 1 January 2008 and 31 December 2015.Demographic data, cancer type, causes of respiratory failure, comorbidities, APACHE II scores, treatments, and mortality rates wererecorded.Results: A total number of 583 cancer patients (477 males) were enrolled from the two centers. Of those, 472 patients had lung cancer(81%), while 111 had extrapulmonary malignancies (19%), having similar mortality rates. Causes of respiratory failure were mostlyinvasion of the cancer itself in 84% of cases and due to infection in 12%. ICU mortality rate was 53% and the 1-year mortality rate was80%. APACHE II scores were significantly higher in nonsurvivors (P < 0.001). One-year survival was found to be significantly shorterin females than males (9 days vs. 12 days) in patients with lung cancer.Conclusion: Mortality rates of cancer patients who need ICU support are higher than overall ICU mortality. High APACHE II scoresand female sex seem to be related to mortality in these patients.

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Cite This Article

ADIGÜZEL, N., KIRAKLI, S. C., GÜNGÖR, G., KARAKURT, Z., EDİBOĞLU, Ö., ÇİMEN, P., SALTÜRK, C., MOÇİN, Ö. Y., ANAR, C. M., BALCI, M. K., ALİZOROĞLU, D. (2022). Predictors of mortality in cancer patients who need intensive care unit support: a two center cohort study. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 4, 744–749. https://ajindex.com/articles/610347

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References (11)

Azevedo LCP, Caruso P, Silva UVA, Torelly AP, Silva E, Rezende E, Netto JJ, Piras C, Lobo SMA, Knibel MF et al. Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study. Chest 2014; 146: 1-36.
Soares M, Salluh JIH, Torres VBL, Leal JVL, Spector N. Shortand long-term outcomes of critically ill patients with cancer and prolonged ICU length of stay. Chest 2008; 134: 520-526.
Azoulay E, Afessa B. The intensive care support of patients with malignancy: do everything that can be done. Intensive Care Med 2006; 32: 3-5.
Kress JP, Christenson J, Pohlman AS, Linkin DR, Hall JB. Outcomes of critically ill cancer patients in a university hospital setting. Am J Respir Crit Care Med 1999; 160: 1957-1961.
Larche J, Azoulay E, Fieux F, Mesnard L, Moreau D, Thiery G, Darmon M, Le Gall JR, Schlemmer B. Improved survival of critically ill cancer patients with septic shock. Intensive Care Med 2003; 29: 1688-1695.
Thiery G, Azoulay E, Darmon M, Ciroldi M, De Miranda S, Levy V, Fieux F, Moreau D, Le Gall JR, Schlemmer B. Outcome of cancer patients considered for intensive care unit admission: a hospital-wide prospective study. J Clin Oncol 2005; 23: 4406- 4413. Reichner CA, Thompson JA, O’Brien S, Kuru T Anderson ED. Outcome and code status of lung cancer patients admitted to the medical ICU. Chest 2006; 130: 719-723.
Roques S, Parrot A, Lavole A, Ancel PY, Gounant V, Djibre M, Fartoukh M. Six-month prognosis of patients with lung cancer admitted to the intensive care unit. Intensive Care Med 2009; 35: 2044-2050.
Andrejak C, Terzi N, Thielen S, Bergot E, Zalcman G, Charbonneau P, Jounieaux V. Admission of advanced lung cancer patients to intensive care unit: a retrospective study of 76 patients. BMC Cancer 2011; 11: 159. Lin YC, Tsai YH, Huang CC, Hsu KH, Wang SW, Tsao TC, Lin MC. Outcome of lung cancer patients with acute respiratory failure requiring mechanical ventilation. Respir Med 2004; 98: 43-51.
Boussat S, El’rini T, Dubiez A, Depierre A, Barale F, Capellier G. Predictive factors of death in primary lung cancer patients on admission to the intensive care unit. Intensive Care Med 2000; 26: 1811-1816.
Ewer MS, Ali MK, Atta MS, Morice RC, Balakrishnan PV. Outcome of lung cancer patients requiring mechanical ventilation for pulmonary failure. JAMA 1986; 256: 3364-3366.
Adam AK, Soubani AO. Outcome and prognostic factors of lung cancer patients admitted to the medical intensive care unit. Eur Respir J 2