Role of hepcidin in the diagnosis of sepsis and septic shock in children

While the specificityof PCT and IL-6 was the same as hepcidin, the specificity of WBC and CRP was lower than that of hepcidin.Conclusion: Hepcidin is a more reliable indicator than WBC and CRP levels in distinguishing children with sepsis and septic shockfrom healthy children and nonseptic pediatric ICU patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC),C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock.Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatricintensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21).

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Key Findings & Data:WBC, CRP, PCT,IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 levels were studied in the HCG.Results: In distinguishing the SG and SSG from the HCG, hepcidin sensitivity and specificity were found to be 100%.

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Conclusion & Impact:While the specificityof PCT and IL-6 was the same as hepcidin, the specificity of WBC and CRP was lower than that of hepcidin.Conclusion: Hepcidin is a more reliable indicator than WBC and CRP levels in distinguishing children with sepsis and septic shockfrom healthy children and nonseptic pediatric ICU patients.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC),C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock.Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatricintensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21). WBC, CRP, PCT,IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 levels were studied in the HCG.Results: In distinguishing the SG and SSG from the HCG, hepcidin sensitivity and specificity were found to be 100%. Distinguishingbetween the PICUCG and the SG, hepcidin sensitivity was calculated as 95.6% and specificity was calculated as 100%. The sensitivity ofWBC, CRP, and PCT was lower than that of hepcidin, but the sensitivity of IL-6 was higher than that of hepcidin. While the specificityof PCT and IL-6 was the same as hepcidin, the specificity of WBC and CRP was lower than that of hepcidin.Conclusion: Hepcidin is a more reliable indicator than WBC and CRP levels in distinguishing children with sepsis and septic shockfrom healthy children and nonseptic pediatric ICU patients.

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Cite This Article

YEŞİLBAŞ, O., GEDİKBAŞI, A., ŞEVKETOĞLU, E., PETMEZCİ, M. T., KIHTIR, H. S., DURAMAZ, B. B., BAYDEMIR, C. (2022). Role of hepcidin in the diagnosis of sepsis and septic shock in children. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 3, 517–524. https://ajindex.com/articles/610333

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