AI Summary & Key Takeaways
AI InsightThis study might have proved communication between lungs and kidneys related to proinflammatory cytokines.
📌 3 Key Takeaways
Abstract
Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combinedtreatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross-talk between lungs andkidneys was also determined.Materials and methods: The systemic, lung-specific, and kidney-specific inflammation levels and the bacterial load in lung tissue andbiochemical parameters were investigated after PhiKZ phage therapy and meropenem alone or combined treatments in a pneumoniamouse model induced by the P. aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined by measuringplasma levels of glycocalyx components.Results: The greatest reduction in lung bacterial load was obtained with the combined use of the PhiKZ phage and meropenem. TheC-reactive protein level in the patient group was significantly higher than in the treatment groups and decreased after treatment. Seruminterleukin IL-6 levels were statistically significantly higher than in the phage serum and phage + meropenem groups. Pulmonaryinfection can trigger proinflammatory cytokines such as IL-6, TNF-α, and IL-1β. Increased cytokines trigger insulin resistance in theliver. Lung infection triggers liver inflammation because there is communication between the lungs and liver.Conclusion: Elevated proinflammatory cytokines due to infection were decreased because of the reduced burden of bacterial load aftertreatment. This study might have proved communication between lungs and kidneys related to proinflammatory cytokines.