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Journals / Turkish Journal of Medical Sciences / 2018 / Cilt: 48 - Sayı: 2

Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

Tuncay KÜME
Korcan DEMİR
Ece BÖBER
Gönül ÇATLI
Ayhan ABACI
Hale TUHAN
Sezer ACAR
Özlem GÜRSOY ÇALAN
Pages
378–385
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our study underlinesthat nesfatin-1 may play a role in the development of malnutrition by inhibiting food intake in children.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: Nesfatin-1, an anorexigenic molecule, seems to play a role in appetite regulation and energy homeostasis.
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Key Findings & Data:The goalof this study was to evaluate the relation of nesfatin-1 with anthropometric and metabolic (ghrelin, leptin) parameters in children withidiopathic chronic malnutrition.Materials and methods: The study included 37 underweight and 38 healthy children who were similar regarding age, sex, and pubertalstatus.
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Conclusion & Impact:Our study underlinesthat nesfatin-1 may play a role in the development of malnutrition by inhibiting food intake in children.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: Nesfatin-1, an anorexigenic molecule, seems to play a role in appetite regulation and energy homeostasis. The goalof this study was to evaluate the relation of nesfatin-1 with anthropometric and metabolic (ghrelin, leptin) parameters in children withidiopathic chronic malnutrition.Materials and methods: The study included 37 underweight and 38 healthy children who were similar regarding age, sex, and pubertalstatus. Anthropometric and biochemical (nesfatin-1, ghrelin, and leptin levels) variables were assessed.Results: A total of 37 underweight subjects (mean age 10.5 ± 2.6 years) and 38 heathy subjects (mean age 10.3 ± 2.3 years) wererecruited. Underweight children had significantly higher nesfatin-1 (2.76 ± 0.4 vs. 1.56 ± 0.7, P < 0.001) and lower leptin levels (2.21 ±2.0 vs. 5.21 ± 2.4, P < 0.001) than those of the control subjects. Nesfatin-1 levels were significantly associated with only leptin levels, afteradjusting for age and BMI (r = –0.371, P = 0.001).Conclusion: The present study is the first to evaluate nesfatin-1 levels in relation with anthropometric and metabolic parameters inchildren with chronic malnutrition, who were subsequently found to have significantly higher nesfatin-1 levels. Our study underlinesthat nesfatin-1 may play a role in the development of malnutrition by inhibiting food intake in children.

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Cite This Article

KÜME, T., DEMİR, K., BÖBER, E., ÇATLI, G., ABACI, A., TUHAN, H., ACAR, S., ÇALAN, Ö. G. (2022). Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 2, 378–385. https://ajindex.com/articles/610324

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