SavedAdd your journal

Journals / Turkish Journal of Medical Sciences / 2018 / Cilt: 48 - Sayı: 4

Peripheral arterial disease increases the risk of multidrug-resistant bacteria and amputation in diabetic foot infections

Murat DİZBAY
Kenan HIZEL
Pınar AYSERT YILDIZ
Tuğba ÖZDİL
Özlem GÜZEL TUNÇCAN
Pages
845–850
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Patients shouldbe promptly evaluated and treated for PAD to prevent infections with resistant microorganisms and limb loss.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: The aim of this study was to investigate the microbiological profile and resistance rates of diabetic foot infections(DFIs) and to determine the effect of peripheral arterial disease (PAD) on the microbiology, clinical condition, and treatment outcomes.Materials and methods: Characteristics, laboratory and imaging data, and the treatment modalities of patients admitted to our hospitalwith a diagnosis of DFI (PEDIS classification 3–4) during 2005–2016 were analyzed according to the presence of PAD.Results: Of 112 patients who were included in this study, 86 (76.8%) had PAD.
📊
Key Findings & Data:Patients with PAD were older and had higher amputationrates (P < 0.05).
💡
Conclusion & Impact:Patients shouldbe promptly evaluated and treated for PAD to prevent infections with resistant microorganisms and limb loss.
🔬Design:Research Article
📍Scope:2005–2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Background/aim: The aim of this study was to investigate the microbiological profile and resistance rates of diabetic foot infections(DFIs) and to determine the effect of peripheral arterial disease (PAD) on the microbiology, clinical condition, and treatment outcomes.Materials and methods: Characteristics, laboratory and imaging data, and the treatment modalities of patients admitted to our hospitalwith a diagnosis of DFI (PEDIS classification 3–4) during 2005–2016 were analyzed according to the presence of PAD.Results: Of 112 patients who were included in this study, 86 (76.8%) had PAD. Patients with PAD were older and had higher amputationrates (P < 0.05). A microbiological profile of patients revealed a predominance of gram-positive bacteria (57.1%). Staphylococcus aureusand Streptococcus spp. were the most frequently encountered bacteria. Incidence of Pseudomonas spp. infection was higher in the PADgroup (P < 0.05). Of all patients, 24.1% had multidrug-resistant (MDR) microorganisms in their wound cultures. Presence of MDRbacteria in patients with PAD was 4.9-fold higher than that in patients without PAD (P < 0.05).Conclusion: This retrospective study indicates that PAD has a significant role, especially in elderly patients with DFIs. Patients shouldbe promptly evaluated and treated for PAD to prevent infections with resistant microorganisms and limb loss.

🔖

Cite This Article

DİZBAY, M., HIZEL, K., YILDIZ, P. A., ÖZDİL, T., TUNÇCAN, Ö. G. (2022). Peripheral arterial disease increases the risk of multidrug-resistant bacteria and amputation in diabetic foot infections. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 4, 845–850. https://ajindex.com/articles/610295

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Albrant D. Management of foot ulcers in patients with diabetes. Am Pharm Assoc 2000; 40: 467-474.
  2. Bansal E, Garg A, Bhatia S, Attri A, Chander J. Spectrum of microbial flora in diabetic foot ulcers. Indian J Pathol Microbiol 2008; 51: 204-208.
  3. Saltoğlu N, Kılıçoğlu Ö, Baktıroğlu S, Oşar-Siva Z, Aktaş Ş, Altındaş M, Arslan C, Aslan T, Çelik S, Engin A et al. Diyabetik ayak yarası ve infeksiyonunun tanısı, tedavisi ve önlenmesi: ulusal uzlaşı raporu. Klimik Dergisi 2015; 28: 2-34 (in Turkish). Weintrob A, Sexton D. Clinical manifestations, diagnosis, and management of diabetic infections of the lower extremities. Available online at https://www.uptodate.com/contents/ clinical-manifestations-diagnosis-and-management-ofdiabetic-infections-of-the-lower-extremities. Cade W. Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther 2008; 88: 1322-1335.
  4. Prompers L, Schaper N, Apelqvist J, Edmonds M, Jude E, Mauricio D, Uccioli L, Urbancic V, Bakker K, Holstein P et al. Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study. Diabetologia 2008; 51: 747-755.
  5. Lipsky B, Berendt A, Cornia P, Pile J, Peters E, Armstrong D, Deery HG, Embil JM, Joseph WS, Karchmer AW et al. 2012 Infectious diseases society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. J Am Podiatr Med Assoc 2013; 103: 2-7. Scully B. Diabetic foot infections: microbiology and antibiotic therapy. In: Shrikhande G, McKinsey J, editors. Diabetes and Peripheral Vascular Disease Diagnosis and Management. 1st ed. New York, NY, USA: Springer Science Business Media; 2012. pp. 93-103.
  6. Hartemann-Heurtier A, Robert J, Jacqueminet S, Van GH, Golmard J, Jarlier V, Grimaldi A. Diabetic foot ulcer and multidrug-resistant organisms: risk factors and impact. Diabet Med 2004; 21: 710-715.
  7. Verim S, Taşçı I. Doppler ultrasonography in lower extremity peripheral arterial disease. Türk Kardiyoloji Derneği Arşivi 2013; 4: 248-255. Unwin N. Comparing the incidence of lower extremity amputations across the world: the global lower extremity amputation study. Diabet Med 1995; 12: 14-18.
  8. Magiorakos A, Srinivasan A, Carey R, Carmeli Y, Falagas M, Giske C, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert pr