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Journals / Turkish Journal of Medical Sciences / 2018 / Cilt: 48 - Sayı: 1

Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury

Ayşegül KÜÇÜK
Faruk Metin ÇOMU
Dilek ERER
Barış MARDİN
G. Levent OKTAR
Yiğit KILIÇ
Abdullah ÖZER
Mustafa ARSLAN
Hüseyin DEMİRTAŞ
Pages
187–190
Publication Date
2022-11-05
DOI
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The values ofthe ischemia/reperfusion group were significantly higher than those of the control and ischemia/reperfusion – erdosteine groups (P

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Objective & Hypothesis:Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been welldocumented but its effect on erythrocyte deformability needs further investigation.
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Key Findings & Data:Our aim was to investigate the effect of erdosteineon erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion.Materials and methods: Our study was conducted with 18 Wistar albino rats.
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Conclusion & Impact:The values ofthe ischemia/reperfusion group were significantly higher than those of the control and ischemia/reperfusion – erdosteine groups (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been welldocumented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of erdosteineon erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion.Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized controlgroup (group ‘control’, n = 6), an ischemia/reperfusion group without erdosteine (group ‘ischemia/reperfusion’, n = 6), and an ischemia/reperfusion group with erdosteine at 150 mg kg–1, intraperitoneally (group ‘ischemia/reperfusion – erdosteine’, n = 6). Packs oferythrocytes were prepared from heparinized blood samples and deformability measurements were conducted.Results: Comparisons of the control and ischemia/reperfusion – erdosteine groups revealed similar results (P = 0.051). The values ofthe ischemia/reperfusion group were significantly higher than those of the control and ischemia/reperfusion – erdosteine groups (P

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Cite This Article

KÜÇÜK, A., ÇOMU, F. M., ERER, D., MARDİN, B., OKTAR, G. L., KILIÇ, Y., ÖZER, A., ARSLAN, M., DEMİRTAŞ, H. (2022). Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 1, 187–190. https://ajindex.com/articles/610285

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