Mild to moderate proteinuria is a heralding sign for acute kidney injury and mortality for intensive care unit patients

AKI was defined according to theKidney Disease: Improving Global Outcomes (KDIGO) guidelines.Results: Patients with dipstick urine protein positivity on admission had higher proportion of AKI and 28-day mortality compared todipstick urine protein negative group [164 (59.6%) vs. 111 (44.4%) and 101 (36.7%) vs. 54 (21.6%), P = 0.01 and P 60 mL/min (hazard ratio:1.988, 95% confidence interval 1.380–2.862).Conclusion: Proteinuria before ICU admission is a risk factor for development of AKI within seven days of ICU stay and also is a riskfactor for 28-day mortality, even in patients with GFR > 60 mL/min.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: Lack of early predictors of acute kidney injury is currently delaying timely diagnosis.

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Key Findings & Data:This study was done to evaluatethe relationship between mild to moderate proteinuria and incidence of acute kidney injury (AKI) and 28-day mortality in intensivecare unit (ICU) patients.Material and methods: This observational, retrospective study was conducted in the internal medicine ICU.

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Conclusion & Impact:AKI was defined according to theKidney Disease: Improving Global Outcomes (KDIGO) guidelines.Results: Patients with dipstick urine protein positivity on admission had higher proportion of AKI and 28-day mortality compared todipstick urine protein negative group [164 (59.6%) vs. 111 (44.4%) and 101 (36.7%) vs. 54 (21.6%), P = 0.01 and P 60 mL/min (hazard ratio:1.988, 95% confidence interval 1.380–2.862).Conclusion: Proteinuria before ICU admission is a risk factor for development of AKI within seven days of ICU stay and also is a riskfactor for 28-day mortality, even in patients with GFR > 60 mL/min.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Background/aim: Lack of early predictors of acute kidney injury is currently delaying timely diagnosis. This study was done to evaluatethe relationship between mild to moderate proteinuria and incidence of acute kidney injury (AKI) and 28-day mortality in intensivecare unit (ICU) patients.Material and methods: This observational, retrospective study was conducted in the internal medicine ICU. A total of 796 patients werescreened and 525 patients were used for this analysis. Proteinuria was measured by urine dipstick test. AKI was defined according to theKidney Disease: Improving Global Outcomes (KDIGO) guidelines.Results: Patients with dipstick urine protein positivity on admission had higher proportion of AKI and 28-day mortality compared todipstick urine protein negative group [164 (59.6%) vs. 111 (44.4%) and 101 (36.7%) vs. 54 (21.6%), P = 0.01 and P 60 mL/min (hazard ratio:1.988, 95% confidence interval 1.380–2.862).Conclusion: Proteinuria before ICU admission is a risk factor for development of AKI within seven days of ICU stay and also is a riskfactor for 28-day mortality, even in patients with GFR > 60 mL/min.

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Cite This Article

ARICI, M., TOPELİ, A., YILDIRIM, T., ASLAN, A., PAŞAYEV, T., AKÇAYIR, Ö., ÇETİK, S., EYÜPOĞLU, D., YETER, H. H. (2022). Mild to moderate proteinuria is a heralding sign for acute kidney injury and mortality for intensive care unit patients. Turkish Journal of Medical Sciences, Cilt: 49 - Sayı: 2, 543–550. https://ajindex.com/articles/609996

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