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Journals / Turkish Journal of Medical Sciences / 2021 / Cilt: 51 - Sayı: 4

Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?

Rukiye NAR
Hande ŞENOL
Gülsüm AKGÜN ÇAĞLIYAN
Başak ÜNVER KOLUMAN
Nilay ŞEN TÜRK
Sibel HACIOĞLU
Kadir İLKKILIÇ
Mehmet Nuri BAŞER
Aslı BOZDEMİR
Veysel EROL
Onurcan YILDIRIM
Ömer ÇAĞLIYAN
Nil GÜLER
Pages
2112–2119
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Key words: Lymphoma, Controlling Nutritional Status score, survival, prognosis

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL).
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Key Findings & Data:This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male.
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Conclusion & Impact:Key words: Lymphoma, Controlling Nutritional Status score, survival, prognosis
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Materials and methods: The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1–190). Results: The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high (≥ 2) or low ( 1 (HR = 2.04, p = 0.006), stage IIIA–IVB disease (HR = 2.75, p = 0.001) and the CONUT score (HR = 1.15, p = 0.003) were found statistically significant. In the multivariate analysis for PFS, age ≥ 65 years (HR = 2.02, p = 0.007), stage IIIA–IVB disease (HR = 2.42, p = 0.002) and the CONUT score (HR = 1.19, p = 0.001) were found to be significant parameters. Conclusion: High CONUT score reduces OS and PFS in DLBCL. CONUT score is an independent, strong prognostic index in patients with DLBCL. Key words: Lymphoma, Controlling Nutritional Status score, survival, prognosis

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Cite This Article

NAR, R., ŞENOL, H., ÇAĞLIYAN, G. A., KOLUMAN, B. Ü., TÜRK, N. Ş., HACIOĞLU, S., İLKKILIÇ, K., BAŞER, M. N., BOZDEMİR, A., EROL, V., YILDIRIM, O., ÇAĞLIYAN, Ö., GÜLER, N. (2022). Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?. Turkish Journal of Medical Sciences, Cilt: 51 - Sayı: 4, 2112–2119. https://ajindex.com/articles/609947

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References (11)

  1. Cioroianu AI, Stinga PI, Sticlaru L, Cioplea MD, Nichita L et al. Tumor microenvironment in diffuse large b-cell lymphoma: role and prognosis. Analytical Cellular Pathology (Amsterdam) 2019; 2019: 8586354. doi: 10.1155/2019/8586354
  2. Luan C, Wang F, Wei N, Chen B. Prognostic nutritional index and the prognosis of diffuse large b-cell lymphoma: a metaanalysis. Cancer Cell Int. 2020; 20: 455. doi:10.1186/s12935- 020-01535-x
  3. Yu W, Guo Q, Wang Z, Mao L, Wei J et al. Clinical significance of prognostic nutritional index for patients with diffuse large b-cell lymphoma. Nutr Cancer. 2019; 71 (4): 569-574. doi: 10.1080/01635581.2018.1540718
  4. Kato T, Yaku H, Morimoto T, Inuzuka Y, Tamaki Y et al. Association with controlling nutritional status (CONUT) score and in-hospital mortality and infection in acute heart failure. Sci Rep. 2020 Feb 24; 10 (1): 3320. doi: 10.1038/s41598-020- 60404-9
  5. Okamoto S, Ureshino H, Kidoguchi K, Kusaba K, Kizuka-Sano H et al. Clinical impact of the CONUT score in patients with multiple myeloma. Ann Hematol. 2020 Jan; 99 (1): 113-119. doi: 10.1007/s00277-019-03844-2
  6. Zhou H, Chao W, Cui L, Li M, Zou Y et al. Controlling nutritional status (CONUT) score as immune-nutritional predictor of outcomes in patients undergoing peritoneal dialysis. Clin Nutr. 2020 Aug; 39 (8): 2564-2570. doi: 10.1016/j. clnu.2019.11.018
  7. Kuroda D, Sawayama H, Kurashige J, Iwatsuki M, Eto T et al. Controlling nutritional status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection. Gastric Cancer. 2018 Mar; 21 (2): 204-212. doi: 10.1007/ s10120-017-0744-3
  8. Ureshino H, Kusaba K, Kidoguchi K, Sano H, Nishioka A et al. Clinical impact of the CONUT score and mogamulizumab in adult t cell leukemia/lymphoma. Ann Hematol. 2019 Feb; 98 (2): 465-471. doi: 10.1007/s00277-018-3502-7
  9. Yamamoto M, Saito H, Uejima C, Tanio A, Tada Y et al. Prognostic value of combined tumor marker and controlling nutritional status (CONUT) score in colorectal cancer patients. Yonago Acta Med. 2019 Mar 28; 62 (1): 124-130. doi:10.33160/ yam.2019.03.017
  10. Kanemasa Y, Shimoyama T, Sasaki Y, Hishima T, Omuro Y. Geriatric nutritional risk index as a prognostic factor in patients with diffuse large b cell lymphoma. Ann Hematol. 2018 Jun; 97 (6): 999-1007. doi: 10.1007/s00277-018-3273-1
  11. Park S, Han B, Cho JW, Woo SY, Kim S et al. Effect of nutritional status on survival outcome of diffuse large b-cell lymphoma patients treated with