Journals / Turkish Journal of Medical Sciences / 2020 / Cilt: 50 - Sayı: 4

Nanotoxicity: a challenge for future medicine

Pages
1180–1196
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Nanotoxicity and adverse effectsof nanomaterials in exposed producers, industry workers, and patients make nanomaterials a double-edged sword for future medicine.In order to control and tackle related risks, regulation and legislations should be implemented, and researchers have to conduct jointmultidisciplinary studies in various fields of medical sciences, nanotechnology, nanomedicine, and biomedical engineering.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: Due to nanomaterials’ potential benefits for diagnosis and treatment, they are widely used in medical applicationsand personal care products.
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Key Findings & Data:Nanotoxicology studies such as in vivo-like on 3D humanorgans, cells, advanced genetic studies, and -omic approaches begin to replace conventional methods.
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Conclusion & Impact:Nanotoxicity and adverse effectsof nanomaterials in exposed producers, industry workers, and patients make nanomaterials a double-edged sword for future medicine.In order to control and tackle related risks, regulation and legislations should be implemented, and researchers have to conduct jointmultidisciplinary studies in various fields of medical sciences, nanotechnology, nanomedicine, and biomedical engineering.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: Due to nanomaterials’ potential benefits for diagnosis and treatment, they are widely used in medical applicationsand personal care products. Interaction of nanomaterials, which are very small in size, with tissue, cell and microenvironment, canreveal harmful effects that cannot be created with chemically identical and larger counterparts in biological organisms. In this review, achallenge for future medicine, nanotoxicity of nanomaterials is discussed.Materials and methods: A detailed review of related literature was performed and evaluated as per medical applications of nanomaterialstheir toxicity.Results and conclusion: Most authors state “the only valid technology will be nanotechnology in the next era”; however, there is noconsensus on the impact of this technology on humankind, environment and ecological balance. Studies dealing with the toxic effect ofnanomaterials on human health have also varied with developing technology. Nanotoxicology studies such as in vivo-like on 3D humanorgans, cells, advanced genetic studies, and -omic approaches begin to replace conventional methods. Nanotoxicity and adverse effectsof nanomaterials in exposed producers, industry workers, and patients make nanomaterials a double-edged sword for future medicine.In order to control and tackle related risks, regulation and legislations should be implemented, and researchers have to conduct jointmultidisciplinary studies in various fields of medical sciences, nanotechnology, nanomedicine, and biomedical engineering.

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Cite This Article

YILDIRIM, M. Ş., SAĞLAM, N., AKÇAN, R., AYDOGAN, H. C., TAŞTEKİN, B. (2022). Nanotoxicity: a challenge for future medicine. Turkish Journal of Medical Sciences, Cilt: 50 - Sayı: 4, 1180–1196. https://ajindex.com/articles/609756

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References (13)

  1. Vance ME, Kuiken T, Vejerano EP, McGinnis SP, Hochella MF, Jr. et al. Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory. Beilstein Journal of Nanotechnology 2015
  2. doi: 10.3762/ bjnano.6.181 2. DTU environment, the Danish ecological council and Danish consumer council (2020). The Nanodatabase [online]. Website http://nanodb.dk/en/ [accessed 27 March 2020]. 3. Warheit DB, Sayes CM, Reed KL, Swain KA. Health effects related to nanoparticle exposures: environmental, health and safety considerations for assessing hazards and risks. Pharmacology & Therapeutics 2008
  3. 120 (1): 35-42. doi: 10.1016/j.pharmthera.2008.07.001 4. Seabra A, Durán N. Nanotoxicology of metal oxide nanoparticles. Metals 2015
  4. 5 (2): 934-975. doi: 10.3390/ met5020934 5. Schrand AM, Rahman MF, Hussain SM, Schlager JJ, Smith DA et al. Metal-based nanoparticles and their toxicity assessment. Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology 2010
  5. 2 (5): 544-568. doi: 10.1002/ wnan.103 6. Iijima S, Ichihashi T. Single-shell carbon nanotubes of 1-nm diameter. Nature 1993
  6. 363 (6430): 603-605. doi: 10.1038/363603a0 7. Bethune D, Kiang CH, De Vries M, Gorman G, Savoy R et al. Cobalt-catalysed growth of carbon nanotubes with singleatomic-layer walls. Nature 1993
  7. 363 (6430): 605-607. doi: 10.1038/363605a0 8. Tans SJ, Devoret MH, Dai H, Thess A, Smalley RE et al. Individual single-wall carbon nanotubes as quantum wires. Nature 1997
  8. 386 (6624): 474-477. doi: 10.1038/386474a0 9. Yu MF, Lourie O, Dyer MJ, Moloni K, Kelly TF et al. Strength and breaking mechanism of multiwalled carbon nanotubes under tensile load. Science 2000
  9. 287 (5453): 637-640. doi: 10.1126/science.287.5453.637 10. Berber S, Kwon YK, Tomanek D. Unusually high thermal conductivity of carbon nanotubes. Physical Review Letters 2000
  10. 84 (20): 4613-4616. doi: 10.1103/PhysRevLett.84.4613 11. Gurevitch D, Shuster-Meiseles T, Nov O, Zick Y, Rudich A et al. TiO2 nanoparticles induce insulin resistance in liver-derived cells both directly and via macrophage activation. Nanotoxicology 2012
  11. doi: 10.3109/17435390.2011.625128 12. Mohammadipour A, Fazel A, Haghir H, Motejaded F, Rafatpanah H et al. Maternal exposure to titanium dioxide nanoparticles during pregnancy
  12. impaired memory and decreased hippocampal cell proliferation in rat offspring. Environmental Toxicology and Pharmacology 2014
  13. 37 (2): 617-625. doi: 10.1016/j.etap.2014.01.014 13. Willhite CC, Kar