Nonbiological and biological liver support systems should be used in PHLF to prepare for treatm
📌 3 Key Takeaways
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Objective & Hypothesis:Liver surgery is one of the most complex surgical interventions with high risk and potential for complications.
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Key Findings & Data:Posthepatectomy liver failure (PHLF) is a serious complication of liver surgery that occurs in about 10% of patients undergoing major liver surgery.
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Conclusion & Impact:Nonbiological and biological liver support systems should be used in PHLF to prepare for treatm
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Liver surgery is one of the most complex surgical interventions with high risk and potential for complications. Posthepatectomy liver failure (PHLF) is a serious complication of liver surgery that occurs in about 10% of patients undergoing major liver surgery. It is the main source of morbidity and mortality. Appropriate surgical techniques and intensive care management are important in preventing PHLF. Early start of the liver support systems is very important for the PHLF patient to recover, survive, or be ready for a liver transplant. Nonbiological and biological liver support systems should be used in PHLF to prepare for treatm
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Cite This Article
ACARLI, K., TOPALOĞLU, S., OCAK, İ. (2022). Posthepatectomy liver failure. Turkish Journal of Medical Sciences, Cilt: 50 - Sayı: 6, 1491–1503. https://ajindex.com/articles/609703
RahbariNN, Garden OJ, Padbury R, Maddern G, Koch Met al. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery 2011
doi: 10.1111/j.1477-2574.2011.00319.x 2. Paugam-Burtz C, Janny S, Delefosse D, Dahmani S, Dondero F et al. Prospective validation of the ‘fifty-fifty’ criteria as an early and accurate predictor of death after liver resection in intensive care unit patients. Annals of Surgery 2009
doi: 10.1097/SLA.0b013e31819279cd. 3. Hammond JS, Guha IN, Beckingam IJ, Lobo DN. Prediction, prevention, and management of postresection liver failure. British Journal of Surgery 2011
doi: 10.1002/ bjs.7630 4. Mullen JT, Ribero D, Reddy SK, Donadon M, Zorzi Det al. Hepatic insufficiency and mortality in 1059 noncirrhotic patients undergoing major hepatectomy. Journal of the American College of Surgeons 2007
doi: 10.1002/jcp.21172 6. Fausto N. Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 2004
doi: 10.1002/hep.20214 7. Clavien PA, Oberkofler CE, Raptis DA, Lehmann K,Rickenbacher A, El-Badry AM. What is critical for liver surgery and partial liver transplantation: size or quality? Hepatology 2010
doi: 10.1002/hep.23713 8. Demetris AJ, Kelly DM, Eghtesad B, Fontes P, Marsh JW et al. Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome. American Journal of Surgical Pathology 2006
doi: 10.1097/00000478-200608000-00009 9. Cornell R. Gut-derived endotoxin elicits hepatotrophic factor secretion of liver regeneration. American Journal of Physiology 1985
R551-R562. doi: 10.1152/ ajpregu.1985.249.5.R551 10. Boermeester MA, Straatsburg IH, Houdijk AP, Meyer C, Frederiks WM et al. Endotoxin and interleukin-1 related hepatic inflammatory response promotes liver failure after partial hepatectomy. Hepatology 1995
doi: 10.1002/hep.1840220525 11. Panis Y, McMullan DM, Emond JC. Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection. Surgery 1997
doi: 10.1016/s0039-6060(97)90283-x 12. Jaeschke H. Molecular mechanisms of hepatic ischemia– reperfusion injury and preconditioning. American Jour