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Journals / Turkish Journal of Medical Sciences / 2020 / Cilt: 50 - Sayı: 4

Effects of oral/enteral nutrition alone versus plus pantoprazole on gastrointestinal bleeding in critically ill patients with low risk factor: a multicenter, randomized controlled trial

Kürşat GÜNDOĞAN
Şahin TEMEL
Muhammet GÜVEN
Murat SUNGUR
Emre KARAKOÇ
Turgut TEKE
Avşar ZERMAN
Aliye ESMAOĞLU
Pages
776–783
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Overall, 226 (75%) patients werefed by orally and 74 (25%) patients fed by enteral tube feeding.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: Critically ill patients are at risk of developing gastrointestinal (GI) bleeding due to stress causing mucosal damage.Aim of the study was to determine the effect of oral/enteral nutrition with or without concomitant pantoprazole on upper GI bleedingin low risk critically ill patients.Materials and methods: This was a prospective, randomized, open-label, multicenter study conducted with intensive care unit (ICU)patients receiving oral/enteral nutritional support.
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Key Findings & Data:Patients were randomly assigned into two groups including intervention group(received oral/EN plus pantoprazole) and control group (received only oral/EN).Results: A total of 300 patients (intervention group: 152, control group: 148) participated in the study.
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Conclusion & Impact:Overall, 226 (75%) patients werefed by orally and 74 (25%) patients fed by enteral tube feeding.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: Critically ill patients are at risk of developing gastrointestinal (GI) bleeding due to stress causing mucosal damage.Aim of the study was to determine the effect of oral/enteral nutrition with or without concomitant pantoprazole on upper GI bleedingin low risk critically ill patients.Materials and methods: This was a prospective, randomized, open-label, multicenter study conducted with intensive care unit (ICU)patients receiving oral/enteral nutritional support. Patients were randomly assigned into two groups including intervention group(received oral/EN plus pantoprazole) and control group (received only oral/EN).Results: A total of 300 patients (intervention group: 152, control group: 148) participated in the study. Overall, 226 (75%) patients werefed by orally and 74 (25%) patients fed by enteral tube feeding. Median duration of nutritional support 4 (range: 2–33) days. Overt upperGI bleeding was noted only in one patient (0.65%) who was in the intervention group. The overall length of ICU stay of 4 (2–105) days,while ICU stay was significantly longer in the intervention group than in the control group (P = 0.006).Conclusions: Our findings seems to indicate that in patients who are at low risk for GI bleeding and under oral/enteral nutritionalsupport, the use of PPIs may not reduce the risk of bleeding, however these results are imprecise because of low event (GI bleeding) rateand limited power.

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Cite This Article

GÜNDOĞAN, K., TEMEL, Ş., GÜVEN, M., SUNGUR, M., KARAKOÇ, E., TEKE, T., ZERMAN, A., ESMAOĞLU, A. (2022). Effects of oral/enteral nutrition alone versus plus pantoprazole on gastrointestinal bleeding in critically ill patients with low risk factor: a multicenter, randomized controlled trial. Turkish Journal of Medical Sciences, Cilt: 50 - Sayı: 4, 776–783. https://ajindex.com/articles/609626

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