SavedAdd your journal

Journals / Turkish Journal of Medical Sciences / 2021 / Cilt: 51 - Sayı: 3

Severe chronic periodontitis is not common in Acromegaly: Potential protective role of gingival BMP-2

0000-0001-5305-6807
Neslihan BAŞÇIL TÜTÜNCÜ
Melek Eda ERTÖRER
Sibel BAŞÇIL
Nilüfer BAYRAKTAR
Pages
1172–1178
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

BMP-2 might have a protective role against chronic advanced periodontitis in these patients.Key words: Acromegaly, periodontitis, growth hormone, bone morphogenetic protein-2, bone morphogenetic protein-4

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim : Advanced chronic periodontitis is observed rarely in acromegaly.
📊
Key Findings & Data:Chronic elevation of growth hormone, IGF-1, and bone morphogenetic proteins may play a role in periodontal tissue regeneration in acromegalics.
💡
Conclusion & Impact:BMP-2 might have a protective role against chronic advanced periodontitis in these patients.Key words: Acromegaly, periodontitis, growth hormone, bone morphogenetic protein-2, bone morphogenetic protein-4
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim : Advanced chronic periodontitis is observed rarely in acromegaly. Periodontal tissue including the alveolar bone is seemed to be spared from the systemic metabolic derangements of bone in this patient population. Chronic elevation of growth hormone, IGF-1, and bone morphogenetic proteins may play a role in periodontal tissue regeneration in acromegalics. In this study, we aimed to evaluate the potential roles of local gingival bone morphogenetic proteins (BMP) in periodontal tissue pathology in acromegaly.Materials and methods: Thirty-five patients with acromegaly and 22 healthy subjects were recruited. All the participants were examined by the same periodontologist for the diagnosis of periodontal diseases. BMP-2 and -4 were studied in gingival crevicular fluid. Results: Gingival BMP-2 and BMP-4 levels were similar in acromegaly and control groups in general, with and without chronic periodontitis. For all the participants, gingival BMP-2 levels were statistically lower in those participants with chronic periodontitis then those without periodontitis (29.4 ± 11.2 vs. 41.2 ± 23.2, respectively, p = 0.027). Causal relation between the gingival BMP levels and periodontal tissue health status was tested with one way ANOVA which revealed a significant difference between gingival BMP2 levels in those with different degrees of periodontal tissue pathology (p = 0.025). When analyzed separately, gingival BMP-2 levels revealed a causal relation with the degree of periodontal pathology with borderline significance only in patients with acromegaly (p = 0.057). Conclusion: Acromegaly is a disease with an unexpectedly low frequency of advanced periodontitis, irrespective of the long disease duration and pathognomonic oral manifestations. BMP-2 might have a protective role against chronic advanced periodontitis in these patients.Key words: Acromegaly, periodontitis, growth hormone, bone morphogenetic protein-2, bone morphogenetic protein-4

🔖

Cite This Article

0000-0001-5305-6807, 0., TÜTÜNCÜ, N. B., ERTÖRER, M. E., BAŞÇIL, S., BAYRAKTAR, N. (2022). Severe chronic periodontitis is not common in Acromegaly: Potential protective role of gingival BMP-2. Turkish Journal of Medical Sciences, Cilt: 51 - Sayı: 3, 1172–1178. https://ajindex.com/articles/609555

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Lesse GP, Fraser WD, Farquharson R, Hipkin L, Vora JP. Gonadal status is an important determinant of bone density in acromegaly. Clinical Endocrinology (Oxf.) 1998
  2. 48 (1): 59-65 DOI: 10.1046/j.1365-2265.1998.00349.x 2. Fredstorp L, Pernow Y, Werner S. The short and long-term effects of octreotide on calcium homeostasis in patients with acromegaly. Clinical Endocrinology (Oxf.) 1993
  3. 39 (3): 331- 336 DOI: 10.1111/j.1365-2265.1993.tb02373.x. 3. Waxler R. Acromegaly. American Journal of Orthodontics and Dentofacial Orthopedics 2007
  4. 131 (1): 6 DOI: 10.1016/j. ajodo.2006.11.011 4. Capoglu I, Yilmaz AB, Unuvar N, Orbak R, Aksoy H et al. Gingival enlargement in acromegaly. Endocrine 2002
  5. 18 (3): 207-210 DOI: 10.1385/ENDO:18:3:207 5. Lima DL, Montenegro RM, Jr., Vieira AP, Albano MF, Rego DM. Absence of periodontitis in acromegalic patients. Clinical Oral Investigation. 2009
  6. 13(2):165-169 DOI: 10.1007/s00784- 008-0216-6 6. Bascil S, Serinsoz H, Tutuncu NB. Acromegaly is protective for periodontal tissue - advanced chronic periodontitis is rare in acromegalics. Bratislavske Lekarske Listy. 2014
  7. 115(9):588-592 7. Al-Kharobi H, El-Gendy R, Devine DA, Beattie J. The role of the insulinlike growth factor (IGF) axis in osteogenic and odontogenic differentiation. Cellular and Molecular Life Sciences. 2014
  8. 71(8):1469-1476 DOI: 10.1007/s00018-013- 1508-9 8. Li H, Bartold PM, Zhang CZ, Clarkson RW, Young WG et al. Growth hormone and insulin-like growth factor I induce bone morphogenetic proteins 2 and 4: a mediator role in bone and tooth formation? Endocrinology. 1998
  9. 139(9):3855-3862 DOI: 10.1210/endo.139.9.6211 9. King GN, Cochran DL. Factors that modulate the effects of bone morphogenetic protein-induced periodontal regeneration: a critical review. Journal of Periodontology. 2002
  10. 73(8):925-936 DOI: 10.1902/jop.2002.73.8.925 10. Mi HW, Lee MC, Fu E, Chow LP, Lin CP. Highly efficient multipotent differentiation of human periodontal ligament fibroblasts induced by combined BMP4 and hTERT gene transfer. Gene Therapy. 2011
  11. 18(5):452-461 DOI: 10.1038/ gt.2010.158 11. Griffiths GS, Curtis MA, Wilton JM. Selection of a filter paper with optimum properties for the collection of gingival crevicular fluid. Journal of Periodontal Research. 1988
  12. 23(1):33-8 12. Harb AN, Holtfreter B, Friedrich N, Wallaschofski H, Nauck M et al. Evaluation of the periodontal status in acromegalic patients: a comparative study. ISRN Dentistry. 2012
  13. 950486 DOI: 10.5402/2012/950486 13. Ozdemir