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Journals / Turkish Journal of Medical Sciences / 2021 / Cilt: 51 - Sayı: 5

An immunohistochemical examination of cinnamon extract administration on distribution of NGF (nerve growth factor) and Trk-A (tyrosine kinase-A) receptor for diabetic rats with pancreatic tissue

Ebru KARADAĞ SARI
Şükran YEDİEL ARAS
Pages
2771–2785
Publication Date
2022-11-06
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: As a result, it was determined that the cinnamon, which is effective on blood glucose levels, has a positive effect on the NGF production in pancreas.Key words: Cinnamon, diabetes, female and male rats, NGF, pancreas, Trk-A

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: The aim of this study was to investigate the administration of cinnamon extract that is known to be effective in decreasing the high blood glucose and the distribution of NGF and Trk-A receptor in pancreas with immunohistochemistry way.
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Key Findings & Data:Materials and methods: The experimental groups were defined as control, sham, cinnamon, diabetes, and diabetes-cinnamon.
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Conclusion & Impact:Conclusion: As a result, it was determined that the cinnamon, which is effective on blood glucose levels, has a positive effect on the NGF production in pancreas.Key words: Cinnamon, diabetes, female and male rats, NGF, pancreas, Trk-A
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: The aim of this study was to investigate the administration of cinnamon extract that is known to be effective in decreasing the high blood glucose and the distribution of NGF and Trk-A receptor in pancreas with immunohistochemistry way. Materials and methods: The experimental groups were defined as control, sham, cinnamon, diabetes, and diabetes-cinnamon. At the end of the experiment, the pancreatic tissue samples were obtained for the rats. The hematoxylin-eosin and triple staining were used to examine histology. The immunohistochemical methods were performed on the sections of pancreatic tissue. In all groups, the body weight and fasting blood glucose obtained from the male and female rats and the values were statistically evaluated. Results: The NGF immunoreactivity was observed in acinus, excretory pars, excretorius ducts, and islets of Langerhans for the pancreatic tissues of female and male rats in all groups. The Trk-A immunoreactivity was observed in acinus and islets of Langerhans for the pancreatic tissues of female and male rats in the control, sham, and cinnamon groups. Conclusion: As a result, it was determined that the cinnamon, which is effective on blood glucose levels, has a positive effect on the NGF production in pancreas.Key words: Cinnamon, diabetes, female and male rats, NGF, pancreas, Trk-A

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Cite This Article

SARI, E. K., ARAS, Ş. Y. (2022). An immunohistochemical examination of cinnamon extract administration on distribution of NGF (nerve growth factor) and Trk-A (tyrosine kinase-A) receptor for diabetic rats with pancreatic tissue. Turkish Journal of Medical Sciences, Cilt: 51 - Sayı: 5, 2771–2785. https://ajindex.com/articles/609387

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