Journals / Turkish Journal of Medical Sciences / 2021 / Cilt: 51 - Sayı: 3

Prognostic value of the C-reactive protein to albumin ratio in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

Pages
1281–1288
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition, the presence of ≥ 2 vascular lesions contributed to a 2-fold increase in mortality rate in STEMI patients.Key words: CRP/albumin ratio, infarction localization, prognosis, ST-elevation myocardial infarction, vascular lesion number

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: This study investigated whether baseline serum level of C-reactive protein (CRP)/albumin ratio is associated with infarct localization, number of vascular lesions, and in-hospital mortality in patients undergoing primary percutaneous coronary intervention (PCI) for acute ST elevation myocardial infarction (STEMI).
📊
Key Findings & Data:Methods: The study population consisted of 116 patients diagnosed with STEMI.
💡
Conclusion & Impact:In addition, the presence of ≥ 2 vascular lesions contributed to a 2-fold increase in mortality rate in STEMI patients.Key words: CRP/albumin ratio, infarction localization, prognosis, ST-elevation myocardial infarction, vascular lesion number
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: This study investigated whether baseline serum level of C-reactive protein (CRP)/albumin ratio is associated with infarct localization, number of vascular lesions, and in-hospital mortality in patients undergoing primary percutaneous coronary intervention (PCI) for acute ST elevation myocardial infarction (STEMI). Methods: The study population consisted of 116 patients diagnosed with STEMI. The CRP/albumin ratio at first admission, cardiac troponin-I (cTnI), PCI results, and clinical outcomes were recorded. Results: The mean CRP/albumin ratio, cTnI level, and mean number of vascular lesions were significantly higher in non-survivors than in survivors (p = 0.006, p = 0.004, and p = 0.007, respectively). Multivariate logistic regression analysis demonstrated that the CRP/ albumin ratio and number of coronary artery lesions were independent predictors of mortality in STEMI patients. According to these analyses, the presence of ≥ 2 vessel lesions was the most important predictor of mortality, with an odds ratio of 2.009 (95% confidence interval: 1.191–3.387, p = 0.009). Conclusion: This study demonstrates the potential utility of the CRP/albumin ratio for predicting the clinical outcome of patients with STEMI. In addition, the presence of ≥ 2 vascular lesions contributed to a 2-fold increase in mortality rate in STEMI patients.Key words: CRP/albumin ratio, infarction localization, prognosis, ST-elevation myocardial infarction, vascular lesion number

🔖

Cite This Article

CAN, M. M., SÖĞÜT, Ö., AKDEMİR, T. (2022). Prognostic value of the C-reactive protein to albumin ratio in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Turkish Journal of Medical Sciences, Cilt: 51 - Sayı: 3, 1281–1288. https://ajindex.com/articles/609385

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Mc Namara K, Alzubaidi H, Jackson JK. Cardiovascular disease as a leading cause of death: how are pharmacists getting involved? Integrated Pharmacy Research & Practice 2019
  2. doi: 10.2147/IPRP.S133088 2. Shrivastava AK, Singh HV, Raizada A, Singh SK. C-reactive protein, inflammation and coronary heart disease. The Egyptian Heart Journal 2015
  3. 67 (2): 89-97. doi: 10.1016/j. ehj.2014.11.005 3. Francula-Zaninovic S, Nola IA. Management of measurable variable cardiovascular disease’ risk factors. Current Cardiology Reviews 2018
  4. 14 (3): 153-163. doi: 10.2174/1573403X14666180222102312 4. Madjid M and Willerson JT. Inflammatory markers in coronary heart disease. British Medical Bulletin 2011
  5. 100 (1): 23-38. doi: 10.1093/bmb/ldr043 5. Wang J, Tan GJ, Han LN, Bai YY, He M et al. Novel biomarkers for cardiovascular risk prediction. Journal of Geriatric Cardiology 2017
  6. 14 (2): 135-150. doi: 10.11909/j.issn.1671- 5411.2017.02.008 6. Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. The New England Journal of Medicine 2004
  7. 350 (14): 1387-1397. doi: 10.1056/NEJMoa032804 7. Calabrò P, Golia E, Yeh ET. Role of C-reactive protein in acute myocardial infarction and stroke: possible therapeutic approaches. Current Pharmaceutical Biotechnology 2012
  8. 13 (1): 4-16. doi: 10.2174/138920112798868764 8. Arques S. Human serum albumin in cardiovascular diseases. European Journal of Internal Medicine 2018
  9. doi: 10.1016/j.ejim.2018.04.014 9. Arques S. Serum albumin and cardiovascular diseases: a comprehensive review of the literature. Annales de Cardiologie et D’angéiologie 2018
  10. 67 (2): 82-90. doi: 10.1016/j. ancard.2018.02.002 10. Nelson JJ, Liao D, Sharrett AR, Folsom AR, Chambless LE et al. Serum albumin level as a predictor of incident coronary heart disease: the Atherosclerosis Risk in communities (ARIC) study. American Journal of Epidemiology 2000
  11. 151 (5): 468-477. doi: 10.1093/oxfordjournals.aje.a010232 11. Djoussé L, Rothman KJ, Cupples LA, Levy D, Ellison RC. Effect of serum albumin and bilirubin on the risk of myocardial infarction (the Framingham offspring study). The American Journal of Cardiology 2003
  12. 91 (4): 485-488. doi: 10.1016/s0002- 9149(02)03256-3 12. Gibson DJ, Hartery K, Doherty J, Nolan J, Keegan D et al. CRP/ Albumin ratio: an early predictor of steroid responsiveness in acute severe Ulcerative Colitis. Journa