Journals / Turkish Journal of Hematology / 2019 / Cilt: 36 - Sayı: 2

Prognostic Factors in Elderly Patients with Diffuse Large B-Cell Lymphoma and Their Treatment Results

Yaşlıların Diffüz Büyük B Hücreli Lenfoması Tedavi Sonuçları ve Etkileyen Prognostik Faktörler

Pages
81–87
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Median overall survival (OS)was 55 months and median progression-free survival was calculatedas 27 months.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Diffuse large B-cell lymphoma (DLBCL) is the mostcommon type of non-Hodgkin lymphoma (NHL).
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Key Findings & Data:Here,we analyze the progress of our own elderly DLBCL patients who werefollowed between 2000 and 2016 in our center.Materials and Methods: Eighty-seven DLBCL patients, who werediagnosed and treated in the Dokuz Eylül University Department ofHematology between 2000 and 2016, were included in this study.Median age was 72 (65-89) years and 13 (14.9%) patients were olderthan 80 years.Results: Median follow-up time was 19 months and 45 patients(51.7%) died during the follow-up period.
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Conclusion & Impact:Median overall survival (OS)was 55 months and median progression-free survival was calculatedas 27 months.
🔬Design:Research Article
📍Scope:2000 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Diffuse large B-cell lymphoma (DLBCL) is the mostcommon type of non-Hodgkin lymphoma (NHL). The treatment ofolder NHL patients has always been a struggle; however, treatmentstatistics have begun showing favorable results similar to those ofyounger DLBCL patients thanks to newer treatment protocols. Here,we analyze the progress of our own elderly DLBCL patients who werefollowed between 2000 and 2016 in our center.Materials and Methods: Eighty-seven DLBCL patients, who werediagnosed and treated in the Dokuz Eylül University Department ofHematology between 2000 and 2016, were included in this study.Median age was 72 (65-89) years and 13 (14.9%) patients were olderthan 80 years.Results: Median follow-up time was 19 months and 45 patients(51.7%) died during the follow-up period. Median overall survival (OS)was 55 months and median progression-free survival was calculatedas 27 months. Sixty-three patients (72.4%) received standard R-CHOPtherapy. Complete response was seen in 46 (52.9%) patients. Themedian survival time for patients who had complete response was 136months (p80 years) and younger patients (p=0.236).Conclusion: According to our findings, we think that being able tocomplete standard R-CHOP therapy is vital for the survival rate ofelderly DLBCL patients.

Özet

Amaç: Diffüz büyük B hücreli lenfoma (DBBHL), Hodgkin dışı lenfomalar (NHL) arasında en sık görülen tiptir. Yaşlı NHL hastalarının tedavisi genellikle zorlu olmakla beraber günümüzde gelişen tedavi protokolleri ile birlikte yaşlı hastalarda da genç DBBHL hastalarına benzer oranda daha iyimser sonuçlar elde edilmektedir. Bu çalışmaya Dokuz Eylül Üniversitesi Hematoloji Anabilim Dalı’nda 2000-2016 yılları arasında takip ve tedavi edilmiş 87 yaşlı DBBHL hastası dahil edildi. Gereç ve Yöntemler: Yaş ortalaması 72 (65-89), 80 yaşının üzerinde 13 (%14,9) hasta mevcuttu. Ortalama takip süresi 19 ay olup, tüm takip süresinde hastaların 45’inin (%51,7) öldüğü gözlendi. Bulgular: Ortalama genel sağkalım süresi 55 ay iken progresyonsuz sağkalım süresi 27 ay olarak hesaplandı. Hastaların 63’ünün (%72,4) standart R-CHOP tedavisi almış olduğu görüldü. Ek olarak hastaların 46’sında (%52,9) tam yanıt alındığı gözlendi. Tam yanıt izlenen hastaların ortalama genel sağkalım süresi 136 ay olarak saptandı (p

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Cite This Article

ADIYAMAN, S. C., DANYELİ, A. E., TURKYILMAZ, D., ÜNDAR, B., ÖZKAL, S., ALACACIOĞLU, İ., SEVİNDİK, Ö. G., DEMİRKAN, F., PİŞKİN, Ö., ÖZCAN, M. A., ÖZSAN, G. H. (2022). Prognostic Factors in Elderly Patients with Diffuse Large B-Cell Lymphoma and Their Treatment Results. Turkish Journal of Hematology, Cilt: 36 - Sayı: 2, 81–87. https://ajindex.com/articles/606679

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