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Journals / Turkish Journal of Hematology / 2022 / Cilt: 39 - Sayı: 2

Invasive Fungal Infections in Children with Leukemia: Clinical Features and Prognosis

Lösemili Çocuklarda İnvazif Mantar Enfeksiyonları: Klinik Özellikler ve Prognoz

Adalet Meral GÜNEŞ
Melike SEZGİN EVİM
Birol BAYTAN
Melek ERDEM
Şebnem YILMAZ
Mustafa Kemal HACIMUSTAFAOĞLU
Özlem TÜFEKÇİ
Hale ÖREN
Solmaz ÇELEBİ
Beyza ENER
Kevser ÜSTÜN ELMAS
Pages
94–102
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The mean age was significantly older in the IFI group compared to children without IFIs (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The incidence of invasive fungal infections (IFIs) has increased due to intensive chemotherapy in childhood leukemia.
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Key Findings & Data:Materials and Methods: The hospital records of 307 children with acute lymphoblastic leukemia (ALL, n=238), acute myeloid leukemia (AML, n=51), and relapsed leukemia (n=18) between January 2010 and December 2015 were retrospectively evaluated.
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Conclusion & Impact:The mean age was significantly older in the IFI group compared to children without IFIs (p
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The incidence of invasive fungal infections (IFIs) has increased due to intensive chemotherapy in childhood leukemia. The aim of this study was to evaluate the incidence, risk factors, causative pathogens, and impact on survival of IFIs among pediatric leukemia patients. Materials and Methods: The hospital records of 307 children with acute lymphoblastic leukemia (ALL, n=238), acute myeloid leukemia (AML, n=51), and relapsed leukemia (n=18) between January 2010 and December 2015 were retrospectively evaluated. Results: A total of 1213 febrile neutropenia episodes were recorded and 127 (10.4%) of them were related to an IFI. Of 307 children, 121 (39.4%) developed IFIs. The mean age was significantly older in the IFI group compared to children without IFIs (p

Özet

Amaç: Çocukluk çağı lösemisinde yoğun kemoterapi nedeniyle invaziv mantar enfeksiyonlarının (IFI) insidansı artmıştır. Bu çalışmanın amacı, pediatrik lösemi hastalarında IFI’nın insidansını, risk faktörlerini, nedensel patojenleri ve sağkalım üzerindeki etkisini değerlendirmektir. Gereç ve Yöntemler: Ocak 2010 ile Aralık 2015 tarihleri arasında akut lenfoblastik lösemili (ALL, n=238), akut myeloid lösemili (AML, n=51) ve relaps lösemili (n=18) 307 çocukların hastane kayıtları geriye dönük olarak değerlendirildi. Bulgular: Toplam 1213 febril nötropeni atağı kaydedildi ve bunların 127’si (%10,4) IFI ile ilgiliydi. Bu 307 çocuğun 121’i (%39,4) IFI geliştirdi. Ortalama yaş, IFI grubunda IFI olmayan çocuklara kıyasla anlamlı olarak daha büyük bulundu (p

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Cite This Article

GÜNEŞ, A. M., EVİM, M. S., BAYTAN, B., ERDEM, M., YILMAZ, Ş., HACIMUSTAFAOĞLU, M. K., TÜFEKÇİ, Ö., ÖREN, H., ÇELEBİ, S., ENER, B., ELMAS, K. Ü. (2022). Invasive Fungal Infections in Children with Leukemia: Clinical Features and Prognosis. Turkish Journal of Hematology, Cilt: 39 - Sayı: 2, 94–102. https://ajindex.com/articles/606494

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