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Journals / Turkish Journal of Chemistry / 2007 / Cilt: 31 - Sayı: 1

A convenient method for the preparation of 2-aminobenzophenone derivaties under ultrasonic irradiation

Javad SAFAEI-GHOMI
Manouchehr FADAEIAN
Alireza HATAMI
Pages
89–95
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results clearly demonstrated that using ultrasound irradiation results in a high yield within a short reaction time.

📌 3 Key Takeaways

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Objective & Hypothesis:A quick and convenient method for the preparation of 2-aminobenzophenone derivatives is described.This approach consists of the nucleophilic substitution reaction of nitrobenzenes by phenylacetonitrile under conventional and ultrasonic conditions followed by reduction of the produced 2,1-benzisoxazole to 2-aminobenzophenone.
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Key Findings & Data:This 2-step reaction was studied by changing the reaction parameters (reaction temperature, ultrasound power, and reaction time).
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Conclusion & Impact:The results clearly demonstrated that using ultrasound irradiation results in a high yield within a short reaction time.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A quick and convenient method for the preparation of 2-aminobenzophenone derivatives is described.This approach consists of the nucleophilic substitution reaction of nitrobenzenes by phenylacetonitrile under conventional and ultrasonic conditions followed by reduction of the produced 2,1-benzisoxazole to 2-aminobenzophenone. This 2-step reaction was studied by changing the reaction parameters (reaction temperature, ultrasound power, and reaction time). The results clearly demonstrated that using ultrasound irradiation results in a high yield within a short reaction time.

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Cite This Article

SAFAEI-GHOMI, J., FADAEIAN, M., HATAMI, A. (2022). A convenient method for the preparation of 2-aminobenzophenone derivaties under ultrasonic irradiation. Turkish Journal of Chemistry, Cilt: 31 - Sayı: 1, 89–95. https://ajindex.com/articles/602174

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References (24)

  1. D.A. Walsh, Synthesis, 677-88 (1980)
  2. J.C.E. Simpson, CM. Atkinson, K. Schofield and O. Stephenson, J. Chem. Soc. 646-57 (1945)
  3. A. Walser and G. Silverman, J. Heterocycl. Chem. 10, 883-4 (1973)
  4. Y. Nakamura and T. Ukita, Org. Lett. 4, 2317-20 (2002)
  5. A.I. Rachlin, U. S. Patent 3261870 (1962)
  6. G. Gamboni, W. Schmid and A. Sutter, U.S. Patent 4236006, (1980)
  7. E.A. Fehnel, J. Org. Chem. 31, 2899-2902 (1966)
  8. H. Matsumoto and T. Horiuchi, U.S. Patent 6310249 Bl (2001)
  9. A. Capelli, G.P. Mohr, A. Gallelli, M. Rizzo, M. Anzini, S. Vomero, L. Mennumi, F. Ferrari, F. Makovec, M.C.Menziani, P.G.D. Benedetti and G. Giorgi, J. Med. Chem. 47, 2574-86 (2004)
  10. P. Hewawasam, W. Fan, M. Ding, K. Flint, D. Cook, G.D. Goggins, R.A. Myers, V.K. Gribkoff, C.G. Bassard, S.I. Dworetzky, J.E. Starrett and N.J. Lodge, J. Med. Chem. 46, 2819-22 (2003)
  11. H. Ma, A.K.Y. Jen, J. Wu, X. Wu and S. Liu, Chem. Matter. 11, 2218-25 (1999)
  12. J.L. Kim, J.K. Kim, H.N. Cho, D.Y. Kim, C.Y. Kim and S.I. Hong, Macromolecules, 33, 5880-85 (2000)
  13. X.L. Chen and S.A. Jenekhe, Macromolecules, 33, 4610-12 (2000)
  14. Liangde Lu and S.A. Jenekhe, Macromolecules, 34, 6249-54 (2001)
  15. T.W. Kwon, M.M. Alam and S.A. Jenekhe, Chem. Matter. 16, 4657-66 (2004)
  16. L.H. Sternbach, Angew. Chem. Internat. Edit. 10, 34-43 (1971)
  17. G. Semple, H. Ryder, D.P. Rooker, A.R. Batt, D.A. Kendrick, M. Szelke, M. Ohta, M. Satoh, A. Nishiha, S. Akuzawa and K. Miyata, J. Med. Chem. 40, 331-41 (1997)
  18. F. Mauri and S.P.A. Ravizza, U.S. Patent 4511510 (1985)
  19. N. Micale, R. Vairagoundar, A.G. Yakovlev and A.P. Kozikowski, J. Med. Chem. 47, 6455-58 (2004)
  20. M.H. Bolli, J. Marfurt, C. Grisostomi, C. Boss, C. Binkert, P. Hess, A. Treiber, E. Thorin, K. Morrison, S.Buchmann, D. Bur, H. Ramuz, M. Clozel, W. Fischli and T. Weller, J. Med. Chem. 47, 2776-95 (2004)
  21. I.M. Buck, J.W. Black, T. Cooke, D.J. Dunstone, J.D. Gaffen, E.A. Harper, R.A.D. Hull, S.B. Kalindjian, E.J.Lilley, I.D. Linney, C.M.R. Low, K.I.M. Steel, D.A. Sykes, M.J. Tozer and G.F. Watt, J. Med. Chem. 48,6803-12 (2005)
  22. R.V. Coombs, R.P. Danna, M. Denzer, G.E. Hardtmann, B. Huegi, G. Koletar, J. Koletar, H. Ott and E.Jukniewicz, J. Med. Chem. 16, 1237-45 (1973)
  23. W.J. Welstead, J.H.W. Moran, H.F. Stauffer, L.B. Turnbull and L.F. Sancilio, J. Med. Chem. 22, 1074-79 (1979)
  24. J.P. Liou, C.W. Chang, J.S. Song, Y.N. Yang, C.F. Yeh, H.Y. Tseng, Y.K. Lo, Y.L. Chang, CM. Chang and H.P. Hsieh, J. Med. Chem.