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Journals / Turkish Journal of Chemistry / 2009 / Cilt: 33 - Sayı: 5

Synthesis of methyl (E)-2' ,4'' -thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities

Asu USTA
Nurettin YAYLI
Alpay Şengül KARAOĞLU
Nuran YAYLI
Ahmet YAŞAR
Pages
621–632
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Experimental and theoretical calculation showed that δ -truxinic type dimer is the most stable isomer.

📌 3 Key Takeaways

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Objective & Hypothesis:A series of 9 new (E) -thiazachalcones (1-3), and their N -alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa.
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Key Findings & Data:The new compounds (1-6) without dimerization products (7-9) showed good antimicrobial property against Staphylococcus aureus, Listeria monocitogenes, and Enterococcus faecalis.
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Conclusion & Impact:Experimental and theoretical calculation showed that δ -truxinic type dimer is the most stable isomer.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A series of 9 new (E) -thiazachalcones (1-3), and their N -alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa. The new compounds (1-6) without dimerization products (7-9) showed good antimicrobial property against Staphylococcus aureus, Listeria monocitogenes, and Enterococcus faecalis. The possible dimerization products of compounds (1-3) were calculated theoretically. Experimental and theoretical calculation showed that δ -truxinic type dimer is the most stable isomer.

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Cite This Article

USTA, A., YAYLI, N., KARAOĞLU, A. Ş., YAYLI, N., YAŞAR, A. (2022). Synthesis of methyl (E)-2' ,4'' -thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities. Turkish Journal of Chemistry, Cilt: 33 - Sayı: 5, 621–632. https://ajindex.com/articles/602131

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