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Journals / Turkish Journal of Chemistry / 2010 / Cilt: 34 - Sayı: 5

Co(III) catalysed asymmetric ring-opening of epichlorohydrin by salicylaldehyde derivatives: reversal of enantioselectivity and rate acceleration on addition of $AICl_3$

Kadriye AYDIN
Stephen T. ASTLEY
Gamze KOZ
Leman KARADENİZ
Pages
711–718
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For 2,3-dihydroxybenzaldehyde and salicylaldehyde, addition of $AICI _3$to the reaction mixture led to an increase in reaction rate without any decrease in product enantiopurity.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Using asymmetric Cobalt(III) salen catalysts, the ring-opening of epichlorohydrin by 2,3-dihydroxybenzaldehyde and 2,4- dihydroxybenzaldehyde was found to occur at the phenolic groups most distant from the aldehydic group.
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Key Findings & Data:Switching catalysts afforded a reversal in enantioselectivity.
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Conclusion & Impact:For 2,3-dihydroxybenzaldehyde and salicylaldehyde, addition of $AICI _3$to the reaction mixture led to an increase in reaction rate without any decrease in product enantiopurity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Using asymmetric Cobalt(III) salen catalysts, the ring-opening of epichlorohydrin by 2,3-dihydroxybenzaldehyde and 2,4- dihydroxybenzaldehyde was found to occur at the phenolic groups most distant from the aldehydic group. Switching catalysts afforded a reversal in enantioselectivity. For 2,3-dihydroxybenzaldehyde and salicylaldehyde, addition of $AICI _3$to the reaction mixture led to an increase in reaction rate without any decrease in product enantiopurity.

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Cite This Article

AYDIN, K., ASTLEY, S. T., KOZ, G., KARADENİZ, L. (2022). Co(III) catalysed asymmetric ring-opening of epichlorohydrin by salicylaldehyde derivatives: reversal of enantioselectivity and rate acceleration on addition of $AICl_3$. Turkish Journal of Chemistry, Cilt: 34 - Sayı: 5, 711–718. https://ajindex.com/articles/602117

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