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Journals / Turkish Journal of Chemistry / 2015 / Cilt: 39 - Sayı: 5

Synthesis and in vitro cytotoxic activity of novel pyrazolo[1,5-a]pyrimidines and related Schiff bases

Ashraf Sayed HASSAN
Taghrid Shoukry HAFEZ
Souad Abdel Meguid OSMAN
Mamdouh Moawad ALI
Pages
1102–1113
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Pyrazolo[1,5-a]pyrimidines 5a c and 9a c and Schiff bases 11b f were investigated for their cytotoxicity against four human cancer cell lines (colon HCT116, lung A549, breast MCF-7, and liver HepG2) according to SRB assay and the structure activity relationship was discussed.

📌 3 Key Takeaways

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Objective & Hypothesis:The reaction of 5-amino-3-(4-methoxyphenylamino)-N -aryl-1H -pyrazole-4-carboxamides 1a c with ethyl acetoacetate 2 and 2-(4-fluorobenzylidene)malononitrile 6 yielded pyrazolo[1,5-a]pyrimidines 5a c and 9a c, respectively.
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Key Findings & Data:On the other hand, Schiff bases 11a f were obtained upon treatment of carboxamides 1a c with some selected aldehydes 10a and b.
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Conclusion & Impact:Pyrazolo[1,5-a]pyrimidines 5a c and 9a c and Schiff bases 11b f were investigated for their cytotoxicity against four human cancer cell lines (colon HCT116, lung A549, breast MCF-7, and liver HepG2) according to SRB assay and the structure activity relationship was discussed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The reaction of 5-amino-3-(4-methoxyphenylamino)-N -aryl-1H -pyrazole-4-carboxamides 1a c with ethyl acetoacetate 2 and 2-(4-fluorobenzylidene)malononitrile 6 yielded pyrazolo[1,5-a]pyrimidines 5a c and 9a c, respectively. On the other hand, Schiff bases 11a f were obtained upon treatment of carboxamides 1a c with some selected aldehydes 10a and b. The newly synthesized compounds were characterized and confirmed by analytical and spectroscopic data (IR, MS, 1 H NMR, and 13 C NMR). Pyrazolo[1,5-a]pyrimidines 5a c and 9a c and Schiff bases 11b f were investigated for their cytotoxicity against four human cancer cell lines (colon HCT116, lung A549, breast MCF-7, and liver HepG2) according to SRB assay and the structure activity relationship was discussed.

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Cite This Article

HASSAN, A. S., HAFEZ, T. S., OSMAN, S. A. M., ALI, M. M. (2022). Synthesis and in vitro cytotoxic activity of novel pyrazolo[1,5-a]pyrimidines and related Schiff bases. Turkish Journal of Chemistry, Cilt: 39 - Sayı: 5, 1102–1113. https://ajindex.com/articles/602085

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