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Journals / Turkish Journal of Chemistry / 2018 / Cilt: 42 - Sayı: 6

Synthesis of E-stilbene azomethines as potent antimicrobial and antioxidant agents

Ahsan IQBAL
Zulfiqar Ali KHAN
Muhammad USMAN
Ayesha BARI
Muhammad Aamir SAJID
Sohail Anjum SHAHZAD
Shakeel Ahmad KHAN
Abdul H. FAUQ
Pages
1518–1533
Publication Date
2022-11-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results suggest possible use of thesecompounds for the rational design of new antimicrobial and antioxidant agents

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A series of new extensively conjugated E -stilbene azomethines (5a–5h) were synthesized and screened fortheir antioxidant and antimicrobial activity.
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Key Findings & Data:Among the tested compounds, N ’-(4-nitrobenzylidene)-2-((E)-styryl)benzohydrazide (5g) was found to possess potent antimicrobial activity higher than some drugs withsignificant activity reported in the literature, e.g., cefradine and terbinafine hydrochloride.
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Conclusion & Impact:These results suggest possible use of thesecompounds for the rational design of new antimicrobial and antioxidant agents
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A series of new extensively conjugated E -stilbene azomethines (5a–5h) were synthesized and screened fortheir antioxidant and antimicrobial activity. The compounds were tested against bacterial (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus subtilis) and fungal strains (Aspergillus niger, A. flavus, andTrichoderma harzianum) using the agar well diffusion method. Among the tested compounds, N ’-(4-nitrobenzylidene)-2-((E)-styryl)benzohydrazide (5g) was found to possess potent antimicrobial activity higher than some drugs withsignificant activity reported in the literature, e.g., cefradine and terbinafine hydrochloride. Additionally, compounds5a–5h were also evaluated for antioxidant potential using DPPH free radical scavenging and ferric thiocyanate (FTC)assays. Among these, N ’-(4-hydroxybenzylidene)-2-((E)-styryl)benzohydrazide (5e) exhibited significant antioxidantpotential by both assays. Compound 5e demonstrated higher DPPH free radical scavenging activity (IC50 = 22 ± 0.19µ g/mL) than the standard, butylated hydroxytoluene (BHT; IC50 = 28 ± 0.10 µ g/mL). A similar trend was observedfor compound 5e in FTC assay, which exhibited 86 ± 0.19% inhibition, whereas the BHT control showed 81 ± 0.21%inhibition of linoleic acid peroxidase. The structure elucidation of the synthesized compounds was carried out by UV-Vis,FT-IR, 1 H NMR, 13 C NMR, and elemental analysis and mass spectrometry. These results suggest possible use of thesecompounds for the rational design of new antimicrobial and antioxidant agents

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Cite This Article

IQBAL, A., KHAN, Z. A., USMAN, M., BARI, A., SAJID, M. A., SHAHZAD, S. A., KHAN, S. A., FAUQ, A. H. (2022). Synthesis of E-stilbene azomethines as potent antimicrobial and antioxidant agents. Turkish Journal of Chemistry, Cilt: 42 - Sayı: 6, 1518–1533. https://ajindex.com/articles/601973

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