Informationabout the structural, electronic, and physico-chemical properties of the novel compounds, obtained by density functionaltheory application, is also reported.
📌 3 Key Takeaways
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Objective & Hypothesis:The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargylalcohol backbone is described (42%{88% yields).
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Key Findings & Data:A ring closing metathesis reaction and an intramolecular Pauson{Khandreaction of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinoline-substituted dihydropyran and cyclopentenone-pyran, respectively, are also described (54% and 78% yields).
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Conclusion & Impact:Informationabout the structural, electronic, and physico-chemical properties of the novel compounds, obtained by density functionaltheory application, is also reported.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargylalcohol backbone is described (42%{88% yields). A ring closing metathesis reaction and an intramolecular Pauson{Khandreaction of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinoline-substituted dihydropyran and cyclopentenone-pyran, respectively, are also described (54% and 78% yields). Informationabout the structural, electronic, and physico-chemical properties of the novel compounds, obtained by density functionaltheory application, is also reported.
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Cite This Article
GÜMÜŞ, A., GÜMÜŞ, S., YENİDEDE, D. (2022). Isoquinoline-substituted triazole and pyran derivatives: synthesis andcomputational studies. Turkish Journal of Chemistry, Cilt: 40 - Sayı: 4, 655–666. https://ajindex.com/articles/601955
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