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Journals / Turkish Journal of Chemistry / 2017 / Cilt: 41 - Sayı: 2

Synthesis and anticancer and cytotoxic effects of novel 1,4-phenylene-bis-N-thiocarbamoylpyrazole and 1,4-phenylene-bis-pyrazolylthiazole derivatives

Ayşe ŞAHİN YAĞLIOĞLU
Mustafa CEYLAN
Meliha Burcu GURDERE
Yakup BUDAK
Erdoğan KAMO
Pages
179–189
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The low cytotoxicity values of 3a h as well as their high antiproliferative activity were encouraging, but further studies are required on the use of these molecules as anticancer drugs.

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Objective & Hypothesis:Thiazolylpyrazoline derivatives were recently reported as potent anticancer agents.
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Key Findings & Data:In this study, novel 1,4-phenylene-bis-N-thiocarbamoylpyrazoles (3a h) and 1,4-phenylene-bis-pyrazolylthiazoles (5a h) were prepared and screened for their anticancer activities against C6 (rat brain tumor cells) and HeLa (human uterus carcinoma).
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Conclusion & Impact:The low cytotoxicity values of 3a h as well as their high antiproliferative activity were encouraging, but further studies are required on the use of these molecules as anticancer drugs.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Thiazolylpyrazoline derivatives were recently reported as potent anticancer agents. In this study, novel 1,4-phenylene-bis-N-thiocarbamoylpyrazoles (3a h) and 1,4-phenylene-bis-pyrazolylthiazoles (5a h) were prepared and screened for their anticancer activities against C6 (rat brain tumor cells) and HeLa (human uterus carcinoma). Anticancer activity studies were performed as a dose-dependent assay starting with eight concentrations. 5-Fluorouracil (5-FU) was used as a positive control. Compounds 3c, 3d, and 3h were examined and they revealed almost the same activities compared with 5-FU in terms of cell selectivity against C6 cells. Moreover, compounds 3a h had lower cytotoxicity than 5-FU. The low cytotoxicity values of 3a h as well as their high antiproliferative activity were encouraging, but further studies are required on the use of these molecules as anticancer drugs.

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Cite This Article

YAĞLIOĞLU, A. Ş., CEYLAN, M., GURDERE, M. B., BUDAK, Y., KAMO, E. (2022). Synthesis and anticancer and cytotoxic effects of novel 1,4-phenylene-bis-N-thiocarbamoylpyrazole and 1,4-phenylene-bis-pyrazolylthiazole derivatives. Turkish Journal of Chemistry, Cilt: 41 - Sayı: 2, 179–189. https://ajindex.com/articles/601892

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