SavedAdd your journal

Journals / Turkish Journal of Chemistry / 2017 / Cilt: 41 - Sayı: 6

Synthesis of novel 5-substituted phenyl-3-(p-isopropylphenyl)-1-phenylformazan and their biological activities

Ayşe ŞAHİN YAĞLIOĞLU
Hülya ŞENÖZ
Pages
883–891
Publication Date
2022-11-03
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results of the assay indicate that I substituent exhibited higher activity against the cells at the meta and para positions than {CH 3 and {H substituents. 3a { g exhibited both high antiproliferative activities against C6 cells and noncytotoxicity. 3a { g may be anticancer drug candidates.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Novel 1-substituted 3-(p-isopropylphenyl)-5-phenylformazans ( 3a { g ) were synthesized and characterized by elemental analysis, 1 H NMR, and FT-IR techniques and UV-visible spectroscopy.
📊
Key Findings & Data:Antiproliferative activities of 3a { g against HeLa and C6 cells were determined using the BrdU cell proliferation ELISA assay. 5-Florouracil was used as the positive control.
💡
Conclusion & Impact:The results of the assay indicate that I substituent exhibited higher activity against the cells at the meta and para positions than {CH 3 and {H substituents. 3a { g exhibited both high antiproliferative activities against C6 cells and noncytotoxicity. 3a { g may be anticancer drug candidates.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Novel 1-substituted 3-(p-isopropylphenyl)-5-phenylformazans ( 3a { g ) were synthesized and characterized by elemental analysis, 1 H NMR, and FT-IR techniques and UV-visible spectroscopy. Antiproliferative activities of 3a { g against HeLa and C6 cells were determined using the BrdU cell proliferation ELISA assay. 5-Florouracil was used as the positive control. The effects of substituents ({H, {CH 3 , and {I) and their positions ( ortho , meta , and para ) on the antiproliferative activities were evaluated. The results of the assay indicate that I substituent exhibited higher activity against the cells at the meta and para positions than {CH 3 and {H substituents. 3a { g exhibited both high antiproliferative activities against C6 cells and noncytotoxicity. 3a { g may be anticancer drug candidates.

🔖

Cite This Article

YAĞLIOĞLU, A. Ş., ŞENÖZ, H. (2022). Synthesis of novel 5-substituted phenyl-3-(p-isopropylphenyl)-1-phenylformazan and their biological activities. Turkish Journal of Chemistry, Cilt: 41 - Sayı: 6, 883–891. https://ajindex.com/articles/601849

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (25)

  1. Sigeikin, G. I.; Lipunova, G. N.; Pervova, I. G. Russ. Chem. Rev. 2006, 75, 885-900
  2. Mariappan, G.; Korim, R.; Joshi, N. M.; Alam, F.; Hazarika, R.; Kumar, D.; Uriah, T. J. Adv. Pharm. Technol. Res. 2010, 1, 396-400
  3. Desai, K. G.; Desai K. R. J. Heterocycl. Chem. 2006, 43, 1083-1089
  4. Mazaahir, K.; Neena, N.; Gupta, S. D. Chem. Pharm. Bull. 1994, 42, 2363-2364
  5. Babu, A. N.; Nadendla, R. R. J. Pharm. Res. 2011, 4, 983-985
  6. Raval, J. P.; Patel, P. R.; Patel, P. S. International Journal of Chemtech Research 2009, 1, 1548-1553
  7. Samel, A. B.; Pai, N. R. J. Chem. Pharm. Res. 2010, 2, 60-67
  8. Shawali, A.S.; Samy, N. A. J. Adv. Res. 2015, 6, 241-254
  9. Uchiumi, A.; Tanaka, H. Anal. Sci. 1989, 5, 425-428
  10. Tezcan, H. Spectrochim. Acta Part A 2008, 69, 971-979
  11. Abbas, A. A. Tetrahedron 1998, 54, 12421-12428
  12. Buzykin, B. I. Chem. Heterocycl. Compd. 2010, 46, 379-408
  13. Edwards, L. C.; Freeman, H. S.; Claxton, L. D. Mutation Res. 2004, 546, 17-28
  14. Szymczyk, M.; Czajkowski, W.; Stolarski, R. Dyes Pigments 1999, 42, 227-235
  15. Raval, J. P.; Patel, P.; Patel, P. S. International Journal of PharmTech Research 2009, 1, 1548-1553
  16. Marjadi, S. I.; Solanki, J. H.; Patel, A. L. E-J. Chem. 2009, 6, 844-848
  17. Samel, A. B.; Pai, N. R. J. Chem. Pharm. Res. 2010, 2, 60-67
  18. Babu, A. N.; Nadendla, R. R. J. Pharm. Res. 2011, 23, 1349-1352
  19. Tezcan, H. Spectrochimica Acta Part A 2008, 69, 971-979
  20. Senoz, H.; Yldrm, E.; Tezcan, H. Asian J. Chem. 2013, 25, 2989-2993
  21. Yldrm, E. MSc, Department of Chemistry, Hacettepe University, Turkey, 2013
  22. Demirtas, I.; Sahin, A. E-J. Chem. 2013, DOI 10.1155/2013/125286
  23. Demirtas, I.; Sahin, A.; Ayhan, B.; Tekin, S.; Telci, I. Rec. Nat. Prod. 2009, 3, 104-109
  24. Sahin Yagloglu, A.; Akdulum, B.; Erenler, R.; Demirtas, I.; Telci, I.; Tekin, S. Med. Chem. Res. 2013, DOI 10.1007/s00044-012-0297-2.18
  25. Eser, F.; Sahin Yaglioglu, A.; Dolarslan, M.; Aktas, E.; Onal A. J. Text. I. 2016, DOI:10.1080/00405000.2016.1257348.