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Journals / Turkish Journal of Chemistry / 2021 / Cilt: 45 - Sayı: 3

Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant, antimicrobial, enzyme inhibition, and cytotoxic activities

Rezzan ALİYAZICIOĞLU
Şeyda KANBOLAT
Hasan Erdinç SELLİTEPE
Nuran KAHRİMAN
Şengül ALPAY KARAOĞLU
Arif BOZDEVECİ
İnci Selin DOĞAN
Gonca ÇELİK
Ali AYDIN
Nurettin YAYLI
Gözde KILIÇ
Pages
788–804
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The synthesized compounds were characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program’s help.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-β-D-glucosides (15-25) were synthesized to investigate their biological activities.
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Key Findings & Data:An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four different benzaldehydes using an ultrasonic bath.
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Conclusion & Impact:The synthesized compounds were characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program’s help.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-β-D-glucosides (15-25) were synthesized to investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 Gram (-), 4/6 Gram (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, α-amylase, and α- glucosidase) for the all synthesized compounds (1-25) were evaluated. And also, four most active compounds (4, 12, 18a+b, and 25) from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer screening tests against the human retinal normal cell line (RPE). Compound 4 showed HeLa and RPE cancer cell activities as much as cisplatin. The synthesized compounds were characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program’s help.

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Cite This Article

ALİYAZICIOĞLU, R., KANBOLAT, Ş., SELLİTEPE, H. E., KAHRİMAN, N., KARAOĞLU, Ş. A., BOZDEVECİ, A., DOĞAN, İ. S., ÇELİK, G., AYDIN, A., YAYLI, N., KILIÇ, G. (2022). Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant, antimicrobial, enzyme inhibition, and cytotoxic activities. Turkish Journal of Chemistry, Cilt: 45 - Sayı: 3, 788–804. https://ajindex.com/articles/601814

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