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Journals / Turkish Journal of Chemistry / 2018 / Cilt: 42 - Sayı: 2

The synthesis of new oxindoles as analogs of natural product 3,3′ -bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PDand 6PGD

Sinan BAYINDIR
Adnan AYNA
Mehmet ÇİFTCİ
Yusuf TEMEL
Pages
332–345
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As indole derivative 5 was an activator of 6PGD and inhibitor of G6PD, it was selected for docking studies to understand the mechanism of activation and inhibition.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Natural and synthetic derivatives that contain an indole core are being used in medical treatments and technological processes.
📊
Key Findings & Data:In this study, new oxindoles with reaction of 4,7-dihydro-1H -indole (2) and isatin (4) were synthesized as analogs of natural product 3,3′ -bis(indolyl)oxindole.
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Conclusion & Impact:As indole derivative 5 was an activator of 6PGD and inhibitor of G6PD, it was selected for docking studies to understand the mechanism of activation and inhibition.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Natural and synthetic derivatives that contain an indole core are being used in medical treatments and technological processes. Therefore, the development of new synthetic methods for the synthesis of indole derivatives is very popular. In this study, new oxindoles with reaction of 4,7-dihydro-1H -indole (2) and isatin (4) were synthesized as analogs of natural product 3,3′ -bis(indolyl)oxindole. The biological properties of the compounds obtained during this study were also studied, showing that compounds 5, 7, and 12 inhibited the activity of G6PD with an IC50 of 99 µM, 231 µM, and 304 µM respectively. The activity of rat erythrocyte 6PGD was increased in the presence of 5 and 7 and was inhibited in the presence of 12. As indole derivative 5 was an activator of 6PGD and inhibitor of G6PD, it was selected for docking studies to understand the mechanism of activation and inhibition.

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Cite This Article

BAYINDIR, S., AYNA, A., ÇİFTCİ, M., TEMEL, Y. (2022). The synthesis of new oxindoles as analogs of natural product 3,3′ -bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PDand 6PGD. Turkish Journal of Chemistry, Cilt: 42 - Sayı: 2, 332–345. https://ajindex.com/articles/601761

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