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Journals / Turkish Journal of Chemistry / 2019 / Cilt: 43 - Sayı: 3

Electrochemical oxidation of curcuminoids: an experimental and computational investigation

Nurgül KARADAŞ
Zeynep KALAYCIOĞLU
Mehmet Emin ÇINAR
Sibel AYŞIL ÖZKAN
Durişehvar ÖZER ÜNAL
Ayşegül GÖLCÜ
Fatma Bedia BERKER
Pages
834–845
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The outcome is supported by density functional theory computations indicating the transfer of 4-e − /H + , 6-e − /H + , and 8-e − /H + couples involved in the oxidation mechanisms of CRM, DMC, and BDMC, respectively, leading to the formationof the same oxidized product.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Curcuminoids, reported to have important biological properties, such as antioxidant, anti-Alzheimer, andantidiabetic properties, comprise curcumin (CRM; 1,7-bis [4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) and its derivatives demethoxycurcumin (DMC; (E,6E)-1-(3,4-dimethoxy-cyclohexyl)-7-(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5- dione) and bisdemethoxycurcumin (BDMC; 1,7-bis[4-hydroxyphenyl]-1,6-heptadiene-3,5-dione).
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Key Findings & Data:The dependence of current intensities and potentials on pH, concentration, scan rate, and nature of the buffer was investigated.
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Conclusion & Impact:The outcome is supported by density functional theory computations indicating the transfer of 4-e − /H + , 6-e − /H + , and 8-e − /H + couples involved in the oxidation mechanisms of CRM, DMC, and BDMC, respectively, leading to the formationof the same oxidized product.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Curcuminoids, reported to have important biological properties, such as antioxidant, anti-Alzheimer, andantidiabetic properties, comprise curcumin (CRM; 1,7-bis [4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) and its derivatives demethoxycurcumin (DMC; (E,6E)-1-(3,4-dimethoxy-cyclohexyl)-7-(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5- dione) and bisdemethoxycurcumin (BDMC; 1,7-bis[4-hydroxyphenyl]-1,6-heptadiene-3,5-dione). Their electrochemical oxidations are thoroughly explored by applying cyclic and differential pulse voltammetric techniques. The dependence of current intensities and potentials on pH, concentration, scan rate, and nature of the buffer was investigated. The outcome is supported by density functional theory computations indicating the transfer of 4-e − /H + , 6-e − /H + , and 8-e − /H + couples involved in the oxidation mechanisms of CRM, DMC, and BDMC, respectively, leading to the formationof the same oxidized product.

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Cite This Article

KARADAŞ, N., KALAYCIOĞLU, Z., ÇINAR, M. E., ÖZKAN, S. A., ÜNAL, D. Ö., GÖLCÜ, A., BERKER, F. B. (2022). Electrochemical oxidation of curcuminoids: an experimental and computational investigation. Turkish Journal of Chemistry, Cilt: 43 - Sayı: 3, 834–845. https://ajindex.com/articles/601702

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