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Journals / Turkish Journal of Chemistry / 2019 / Cilt: 43 - Sayı: 1

Preparation of α-hydroxyphenylacetic acid with cyclodextrins as an effective phase-transfer catalyst and its reaction mechanism

Rui Xia ZHANG
Qing HUANG
Zhi Zhong WANG
Hui Min CHU
Bing Ren TIAN
Pages
359–368
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results indicated that β -CD is the optimalcatalyst for the reported reaction (yield: 69.08%).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:An effective procedure for the synthesis of α-hydroxyphenylacetic acid with cyclodextrin (CD) catalysts wasdeveloped.
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Key Findings & Data:The phase-transfer catalyst types, catalyst loadings, reaction times, reaction temperatures, and substratemolar ratios were investigated to optimize the reaction conditions.
💡
Conclusion & Impact:The results indicated that β -CD is the optimalcatalyst for the reported reaction (yield: 69.08%).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

An effective procedure for the synthesis of α-hydroxyphenylacetic acid with cyclodextrin (CD) catalysts wasdeveloped. The phase-transfer catalyst types, catalyst loadings, reaction times, reaction temperatures, and substratemolar ratios were investigated to optimize the reaction conditions. In addition, the factors that affect the reaction werestudied, and the relationship between benzaldehyde and β -cyclodextrin (β -CD) was analyzed through 2D-ROESY. Theequilibrium constant when β -CD was used as the catalyst was calculated. The results indicated that β -CD is the optimalcatalyst for the reported reaction (yield: 69.08%). Furthermore, the mechanism underlying the reported reaction wasproposed.

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Cite This Article

ZHANG, R. X., HUANG, Q., WANG, Z. Z., CHU, H. M., TIAN, B. R. (2022). Preparation of α-hydroxyphenylacetic acid with cyclodextrins as an effective phase-transfer catalyst and its reaction mechanism. Turkish Journal of Chemistry, Cilt: 43 - Sayı: 1, 359–368. https://ajindex.com/articles/601666

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