The outstanding merits of the current protocol (a)included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reactionsteps due to eliminating separation and purification of intermediates, (c) good yield of the sterically hindered substrates,and (d) avoid the generation of heavy metal or corrosive waste.
📌 3 Key Takeaways
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Objective & Hypothesis:In the current protocol, the arene diazonium saccharin derivatives were initially produced from varioussubstituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for thepreparation of the aryl iodide.
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Key Findings & Data:The arene diazonium saccharin intermediates could be stored in the liquid phaseinto a refrigerator for a long time with no significant loss activity.
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Conclusion & Impact:The outstanding merits of the current protocol (a)included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reactionsteps due to eliminating separation and purification of intermediates, (c) good yield of the sterically hindered substrates,and (d) avoid the generation of heavy metal or corrosive waste.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
In the current protocol, the arene diazonium saccharin derivatives were initially produced from varioussubstituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for thepreparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phaseinto a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol (a)included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reactionsteps due to eliminating separation and purification of intermediates, (c) good yield of the sterically hindered substrates,and (d) avoid the generation of heavy metal or corrosive waste.
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Cite This Article
KHALIGH, N. G., JOHAN, M. R., SHAHNAVAZ, Z., ZAHARANI, L. (2022). Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide. Turkish Journal of Chemistry, Cilt: 44 - Sayı: 2, 535–542. https://ajindex.com/articles/601521
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