However, the inhibitory effect on EROD activity was not significant.
📌 3 Key Takeaways
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Objective & Hypothesis:Several 5-(alkylsulfonyl)-1-substituted-2-(1H-pyrrol-2-yl)-1H-benzo[d]imidazole derivatives were synthesized and their antioxidant activities were investigated using lipid peroxidation (LPO) and 7-ethoxyresorufin O-deethylase (EROD) assays.
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Key Findings & Data:Docking analysis with Human NAD[P]H-Quinone oxidoreductase 1 (NQO1) was also performed to gather thorough information about these compounds that have antioxidant activities.
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Conclusion & Impact:However, the inhibitory effect on EROD activity was not significant.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Several 5-(alkylsulfonyl)-1-substituted-2-(1H-pyrrol-2-yl)-1H-benzo[d]imidazole derivatives were synthesized and their antioxidant activities were investigated using lipid peroxidation (LPO) and 7-ethoxyresorufin O-deethylase (EROD) assays. Docking analysis with Human NAD[P]H-Quinone oxidoreductase 1 (NQO1) was also performed to gather thorough information about these compounds that have antioxidant activities. Moreover, their molecular descriptors and ADME properties were calculated using the SwissADME online program. As a result, most of our compounds possessed better affinity and created ample interactions with NQO1. The most potent compound 5j had LP inhibition value of 3.73 nmol/mg/min. Other compounds exhibited moderate activity on LP levels comparing to standard butylated hydroxy toluene (BHT). However, the inhibitory effect on EROD activity was not significant.
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Cite This Article
KARADAYI, F. Z., KIŞLA, M. M., ALAGÖZ, Z. A., BAŞARAN, R., EKE, B. C. (2022). Synthesis, antioxidant activity, molecular docking and ADME studies of novel pyrrolebenzimidazole derivatives. Turkish Journal of Chemistry, Cilt: 46 - Sayı: 3, 890–902. https://ajindex.com/articles/601377
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