Compound 1 was screened for its antioxidant, lipoxygenase, prolyl endopeptidase, and respiratory burst inhibitory activities. 2ʹ-O-Ethylmurrangatin (1) was found to have significant activity against lipoxygenase enzyme and moderate respiratory burst inhibitory activity, but no activity against either DPPH radical scavenging assay or prolyl endopeptidase enzyme.
📌 3 Key Takeaways
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Objective & Hypothesis:A secondary metabolite, 2ʹ-O-ethylmurrangatin (1), was isolated from the leaves of a medicinal plant, Murraya paniculata.
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Key Findings & Data:The structure of compound 1 was identified with the help of spectroscopic techniques.
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Conclusion & Impact:Compound 1 was screened for its antioxidant, lipoxygenase, prolyl endopeptidase, and respiratory burst inhibitory activities. 2ʹ-O-Ethylmurrangatin (1) was found to have significant activity against lipoxygenase enzyme and moderate respiratory burst inhibitory activity, but no activity against either DPPH radical scavenging assay or prolyl endopeptidase enzyme.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
A secondary metabolite, 2ʹ-O-ethylmurrangatin (1), was isolated from the leaves of a medicinal plant, Murraya paniculata. The structure of compound 1 was identified with the help of spectroscopic techniques. Compound 1 was screened for its antioxidant, lipoxygenase, prolyl endopeptidase, and respiratory burst inhibitory activities. 2ʹ-O-Ethylmurrangatin (1) was found to have significant activity against lipoxygenase enzyme and moderate respiratory burst inhibitory activity, but no activity against either DPPH radical scavenging assay or prolyl endopeptidase enzyme.
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Cite This Article
SHAIKH, A., CHOUDHARY, M. I. (2022). Bioassay studies of 2ʹ-O-ethylmurrangatin isolated from a medicinal plant, Murraya paniculata. Turkish Journal of Biology, Cilt: 35 - Sayı: 6, 751–755. https://ajindex.com/articles/600489
Sastri BN. The Wealth of India, Council of Scientific and Industrial Research, New Delhi, Vol. 6: 446-448, 1962
Perry LM, Metzger J. Medicinal Plants of East and Southeast Asia. The Massachusetts Institute of Technology Press. Cambridge; 1980. p. 367, 3. Choudhary MI, Azizuddin, Khalid A et al. A new coumarin from Murraya paniculata. Planta Med 68: 81-83, 2002
Richard AL. The antioxidants of higher plants. Phytochemistry 27: 969-979, 1988
Floyd RA. DNA-Ferrous iron catalyzed hydroxyl free radical formation from hydrogen peroxide. Biochem Biophys Res Commun 99: 1209-1215, 1981
Shi H, Hiramatsu M, Kamatsu M et al. Antioxidant property of Fructus momordicae extract. Biochem Mol Biol Intl 40: 1111- 1121, 1996
Gross MD, Snowdon D, Snowdon A. Plasma antioxidant concentrations in a population of elderly women: findings from the nun study. Nutrition Research 16: 1881-1890, 1996
Kim YD, Chen B, Beauregard J et al. 17 beta-Estradiol prevents dysfunction of canine coronary endothelium and myocardium and reperfusion arrhythmias after brief ischemia/reperfusion. Circulation 94: 2901-2908, 1996
Land WEM. Mechanisms of action of anti-inflammatory drugs. Advance Drug Research 14: 147-167, 1985
Steinhilber D. 5-Lipoxygenase: A target for anti-inflammatory drugs revisited. Curr Med Chem 6: 71-85, 1999
Nie D, Honn KV. Cyclooxygenase, lipoxygenase and tumor angiogenesis. Cellular and Molecular Life Sciences 59: 799- 807, 2002
Fan W, Komatsu K, Tezuka Y et al. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sacra S. H. Fu. Biol Pharm Bull 22: 157-161, 1999
Szeltner Z, Renner V, Polgar L. Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family. Protein Science 9: 353-360, 2000
Fujita Y, Uehara F, Morimoto Y et al. Studies on inhibition mechanism of autoxidation by tannins and flavonoids. Yakugaku Zasshi 108: 129-135, 1998
Smith RC, Reeves JC, Dage RC et al. Antioxidant properties of 2-imidazolones and 2-imidazolthiones. Biochem Pharmacol 36: 1457-1460, 1987
Tappel AL. Methods in Enzymology, Academic Press, New York, Vol. 05: pp. 539, 1962
Yoshimoto T, Walter R, Suru T. Proline-specific endopeptidase from Flavobacterium. Purification and properties. J Biol Chem 255: 4786-4792, 1980
Tan AS, Berridge VM. Superoxide produced by activated neutrophils efficiently reduces the tetrazolium sa