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Journals / Turkish Journal of Biology / 2016 / Cilt: 40 - Sayı: 2

The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine

Yüksel TERZİ
Hasan ALAÇAM
İbrahim GÖREN
Osman ŞALIŞ
Fatih İLKAYA
Muhammed Emin KELEŞ
Ali OKUYUCU
Abdullah GÜVENLİ
Ömer ALICI
Pages
452–461
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results indicate that ADMA is a factor in the formation of liver injury.

📌 3 Key Takeaways

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Objective & Hypothesis:We aimed to determine whether increased levels of asymmetric dimethylarginine (ADMA) directly cause hepatic deterioration and whether it is decreased by ascorbic acid (AA) as an antioxidant.
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Key Findings & Data:The study included three groups: Control (n = 10), ADMA (n = 10), and ADMA + AA (n = 10).
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Conclusion & Impact:The results indicate that ADMA is a factor in the formation of liver injury.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

We aimed to determine whether increased levels of asymmetric dimethylarginine (ADMA) directly cause hepatic deterioration and whether it is decreased by ascorbic acid (AA) as an antioxidant. The study included three groups: Control (n = 10), ADMA (n = 10), and ADMA + AA (n = 10). ADMA was administered at 2 mg kg-1 day-1 and AA was given at 50 mg kg-1 day-1 for 10 days. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase, and alkaline phosphatase activities were analyzed. Histomorphological evaluation of the liver was performed based on the Ishak scoring system. When compared with the control, ALT and ALP levels of the ADMA group were significantly higher (P = 0.006 and P = 0.041, respectively). When compared with the control, interface hepatitis, confluent necrosis, focal necrosis, histological activity index, severity of hepatitis, and portal inflammation were significantly higher in the group administered ADMA. The mentioned biochemical/histopathological parameters were lower in the ADMA + AA group when compared with the ADMA group even if no significant difference was encountered (P > 0.05). The results indicate that ADMA is a factor in the formation of liver injury. Insufficient recovery in biochemical/histopathological parameters when AA was given make us consider that different factors other than prooxidant factors are effective in the formation of liver injury.

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Cite This Article

TERZİ, Y., ALAÇAM, H., GÖREN, İ., ŞALIŞ, O., İLKAYA, F., KELEŞ, M. E., OKUYUCU, A., GÜVENLİ, A., ALICI, Ö. (2022). The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine. Turkish Journal of Biology, Cilt: 40 - Sayı: 2, 452–461. https://ajindex.com/articles/600380

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