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Journals / Turkish Journal of Biology / 2018 / Cilt: 42 - Sayı: 2

hsa-miR-301a- and SOX10-dependent miRNA-TF-mRNA regulatory circuits in breast cancer

Yasemin ÖZTEMUR ISLAKOĞLU
Senem NOYAN
Bala GÜR DEDEOĞLU
Pages
103–112
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It can be concluded that regulatorymotifs involving miRNAs and TFs may be useful for understanding breast cancer regulation and for predicting new biomarkers.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Breast cancer is the most common cancer among women and the molecular pathways that play main roles in breast cancerregulation are still not completely understood.
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Key Findings & Data:CircuitsDB2 analysis conducted with DE miRNAs and mRNAs resulted in 3 significant circuits that are SOX10- and hsamiR-301a-dependent.
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Conclusion & Impact:It can be concluded that regulatorymotifs involving miRNAs and TFs may be useful for understanding breast cancer regulation and for predicting new biomarkers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Breast cancer is the most common cancer among women and the molecular pathways that play main roles in breast cancerregulation are still not completely understood. MicroRNAs (miRNAs) and transcription factors (TFs) are important regulators of geneexpression. It is important to unravel the relation of TFs, miRNAs, and their targets within regulatory networks to clarify the processesthat cause breast cancer and the progression of it. In this study, mRNA and miRNA expression studies including breast tumors andnormal samples were extracted from the GEO microarray database. Two independent mRNA studies and a miRNA study were selectedand reanalyzed. Differentially expressed (DE) mRNAs and miRNAs between breast tumor and normal samples were listed by using BRBArray Tools. CircuitsDB2 analysis conducted with DE miRNAs and mRNAs resulted in 3 significant circuits that are SOX10- and hsamiR-301a-dependent. The following significant circuits were characterized and validated bioinformatically by using web-based tools:SOX10→hsa-miR-301a→HOXA3, SOX10→hsa-miR-301a→KIT, and SOX10→hsa-miR-301a→NFIB. It can be concluded that regulatorymotifs involving miRNAs and TFs may be useful for understanding breast cancer regulation and for predicting new biomarkers.

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Cite This Article

ISLAKOĞLU, Y. Ö., NOYAN, S., DEDEOĞLU, B. G. (2022). hsa-miR-301a- and SOX10-dependent miRNA-TF-mRNA regulatory circuits in breast cancer. Turkish Journal of Biology, Cilt: 42 - Sayı: 2, 103–112. https://ajindex.com/articles/600272

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