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Journals / Turkish Journal of Biology / 2018 / Cilt: 42 - Sayı: 4

Age- and sex-dependent alteration of functions and epigenetic modifications of vessel and endothelium related biomarkers

Can AKÇALI
Suzan Emel USANMAZ
Sevtap HAN
Mecit Orhan ULUDAĞ
Serdar AKANSEL
Muammer Merve AYDIN
Emine DEMİREL YILMAZ
Pages
286–296
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results indicate that vascular functions, epigenetic modifications of vessels, and plasma levels of endothelium-relatedbiomarkers are affected by age and sex.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aging is a main risk factor for development of cardiovascular diseases associated with the impairment of endothelial functionin both sexes.
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Key Findings & Data:Acetylcholine (ACh)-inducedrelaxations of the aorta were decreased in 3-, 6-, and 12-month-old rats compared to those in 1-month-old female rats.
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Conclusion & Impact:These results indicate that vascular functions, epigenetic modifications of vessels, and plasma levels of endothelium-relatedbiomarkers are affected by age and sex.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aging is a main risk factor for development of cardiovascular diseases associated with the impairment of endothelial functionin both sexes. In the present study, age-related changes in vascular responsiveness, epigenetic modifications of vessel wall, and bloodbiomarkers related to endothelial functions were examined in an age- and sex-dependent manner. Acetylcholine (ACh)-inducedrelaxations of the aorta were decreased in 3-, 6-, and 12-month-old rats compared to those in 1-month-old female rats. In males,maximum relaxations related to ACh were higher in 1- and 6-month-old rats than in 3- and 12-month-old rats. Plasma levels of nitricoxide (NO) and asymmetric dimethylarginine (ADMA) decreased with age in female rats, and total antioxidant capacity (TAC) andhydrogen sulfide ($H_2S$) levels displayed biphasic alterations. In male rats, plasma levels of NO, TAC, and ADMA decreased with age,and H$H_2S$ levels increased. Aging also caused a sex-dependent alteration in epigenetic modification of vessels. Expressions of H3K27me2,H3K27me3, H3K36me2, and H3K36me3 were much higher in vessels of 12-month-old female rats compared to those in younger agegroups. These results indicate that vascular functions, epigenetic modifications of vessels, and plasma levels of endothelium-relatedbiomarkers are affected by age and sex. These findings could be important for the assessment of vascular status over the course of thelife span.

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Cite This Article

AKÇALI, C., USANMAZ, S. E., HAN, S., ULUDAĞ, M. O., AKANSEL, S., AYDIN, M. M., YILMAZ, E. D. (2022). Age- and sex-dependent alteration of functions and epigenetic modifications of vessel and endothelium related biomarkers. Turkish Journal of Biology, Cilt: 42 - Sayı: 4, 286–296. https://ajindex.com/articles/600236

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