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Journals / Turkish Journal of Biology / 2020 / Cilt: 44 - Sayı: 3

Identification of the nucleotide substitutions in 62 SARS-CoV-2 sequences from Turkey

Domenico BENVENUTO
Silvia ANGELETTI
Massimo CICCOZZI
Ayşe Banu DEMİR
Hakan ABACIOĞLU
Pages
178–184
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results indicate that the viral isolates from Turkey harbor some common mutations with the viral strains from Europe, Oceania, North America and Asia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A previously unknown coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to cause coronavirus disease 2019 (COVID-19) pandemic.
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Key Findings & Data:The first case of COVID-19 in Turkey has been declared in March 11th, 2020 and from there on, more than 150,000 people in the country have been diagnosed with the disease.
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Conclusion & Impact:Our results indicate that the viral isolates from Turkey harbor some common mutations with the viral strains from Europe, Oceania, North America and Asia.
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Domain Parameters

Abstract

A previously unknown coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to cause coronavirus disease 2019 (COVID-19) pandemic. The first case of COVID-19 in Turkey has been declared in March 11th, 2020 and from there on, more than 150,000 people in the country have been diagnosed with the disease. In this study, 62 viral sequences from Turkey, which have been uploaded to GISAID database, were analyzed by means of their nucleotide substitutions in comparison to the reference SARS-CoV-2 genome from Wuhan. Our results indicate that the viral isolates from Turkey harbor some common mutations with the viral strains from Europe, Oceania, North America and Asia. When the mutations were evaluated, C3037T, C14408T and A23403G were found to be the most common nucleotide substitutions among the viral isolates in Turkey, which are mostly seen as linked mutations and are part of a haplotype observed high in Europe.

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Cite This Article

BENVENUTO, D., ANGELETTI, S., CICCOZZI, M., DEMİR, A. B., ABACIOĞLU, H. (2022). Identification of the nucleotide substitutions in 62 SARS-CoV-2 sequences from Turkey. Turkish Journal of Biology, Cilt: 44 - Sayı: 3, 178–184. https://ajindex.com/articles/600185

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References (2)

  1. Bai Y, Jiang D, Lon JR, Chen X, Hu M et al. (2020). Evolution and molecular characteristics of SARS-CoV-2 genome. BioRxiv (preprint). doi: 10.1101/2020.04.24.058933 Benvenuto D, Angeletti S, Giovanetti M, Bianchi M, Pascarella S et al. (2020). Evolutionary analysis of SARS-CoV-2: how mutation of non-structural protein 6 (NSP6) could affect viral autophagy. Journal of Infection (in press). doi: 10.1016/j.jinf.2020.03.058 Dorp LV, Richard, Shaw LP (2020). No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2. BioRxiv (preprint). doi: 10.1101/2020.05.21.108506 Eden JS, Rockett R, Carter I, Rahman H, De Ligt J et al. (2020). An emergent clade of SARS-CoV-2 linked to returned travellers from Iran. Virus Evolution 6 (1): 1-4. doi: 10.1093/ve/veaa027 Elbe S, Buckland-Merrett G (2017). Data, disease and diplomacy: GISAID’s innovative contribution to global health. Global Challenges 1 (1): 33-46. doi: 10.1002/gch2.1018 Eskier D, Karakullah G, Suner A, Oktay Y (2020). RdRp mutations areassociated with SARS-CoV-2 genome evolution. BioRxiv (preprint). doi: 10.1101/2020.05.20.104885 Forster P, Forster L, Renfrew C, Forster M (2020). Phylogenetic network analysis of SARS- CoV-2 genomes. Proceedings of the National Academy of Sciences 117 (17): 9241-9243. doi: 10.1073/pnas.2004999117 Goh GKM, Keith Dunker A, Foster JA, Uversky VN (2020). Rigidity of the outer shell predicted by a protein intrinsic disorder model sheds light on the COVID-19 (Wuhan-2019-nCoV) infectivity. Biomolecules 10 (2): 2019-2021. doi: 10.3390/biom10020331 Gorbalenya AE, Baker SC, Baric RS, De Groot RJ, Drosten C et al. (2020). The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARSCoV-2. Nature Microbiology 5 (4): 536-544. doi: 10.1038/ s41564-020-0695-z Hillen HS, Kokic G, Farnung L, DienemannC, Tegunov D et al. (2020). Structure of replicating SARS-CoV-2 polymerase. BioRxiv (preprint). doi: 10.1038/s41586-020-2368-8
  2. Korber B, Fischer W, Gnanakaran SG, Yoon H, Theiler J et al. (2020). Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2. BioRxiv (preprint). doi: 10.1101/2020.04.29.069054 Li J, Li Z, Cui X, Wu C (2020). Bayesian phylodynamic inference on the temporal evolution and global transmission of SARSCoV-2. Journal of Infection: 1-12 [Epub ahead of print]. doi: 10.1016/j.jinf.2020.04.016 Lu J, Plessis L du, Liu Z, Hill V, Kang M et al. (2020). Genomic epidemiology of SARS-CoV-2