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Journals / Turkish Journal of Biology / 2020 / Cilt: 44 - Sayı: 3

An insight into the epitope-based peptide vaccine design strategy and studies against COVID-19

Tülin ARASOĞLU
Burcu UÇAR
Emrah Şefik ABAMOR
Dilek TURGUT BALIK
Erennur UĞUREL
Pelin PELİT ARAYICI
Serap DERMAN
Tayfun ACAR
Murat TOPUZOĞULLARI
Pages
215–227
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We have not only compared the peptide vaccine with other types of vaccines but also presented comprehensive literature information about development steps for an effective and protective formulation to give an insight into on-going peptide vaccine studies against SARS-CoV-2.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:SARS-CoV-2 is a new member of the coronavirus family and caused the pandemic of coronavirus disease 2019 (COVID-19) in 2020.
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Key Findings & Data:In this review, vaccine studies against COVID-19 have been summarized and detailed information about the epitope-based peptide vaccines against COVID-19 has been provided.
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Conclusion & Impact:We have not only compared the peptide vaccine with other types of vaccines but also presented comprehensive literature information about development steps for an effective and protective formulation to give an insight into on-going peptide vaccine studies against SARS-CoV-2.
🔬Design:Review & Systematic Survey
📍Scope:2019 Verileri
⚙️Variables:Domain Parameters

Abstract

SARS-CoV-2 is a new member of the coronavirus family and caused the pandemic of coronavirus disease 2019 (COVID-19) in 2020. It is crucial to design and produce an effective vaccine for the prevention of rapid transmission and possible deaths wcaused by the disease. Although intensive work and research are being carried out all over the world to develop a vaccine, an effective and approved formulation that can prevent the infection and limit the outbreak has not been announced yet. Among all types of vaccines, epitope-based peptide vaccines outshine with their low-cost production, easy modification in the structure, and safety. In this review, vaccine studies against COVID-19 have been summarized and detailed information about the epitope-based peptide vaccines against COVID-19 has been provided. We have not only compared the peptide vaccine with other types of vaccines but also presented comprehensive literature information about development steps for an effective and protective formulation to give an insight into on-going peptide vaccine studies against SARS-CoV-2.

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Cite This Article

ARASOĞLU, T., UÇAR, B., ABAMOR, E. Ş., BALIK, D. T., UĞUREL, E., ARAYICI, P. P., DERMAN, S., ACAR, T., TOPUZOĞULLARI, M. (2022). An insight into the epitope-based peptide vaccine design strategy and studies against COVID-19. Turkish Journal of Biology, Cilt: 44 - Sayı: 3, 215–227. https://ajindex.com/articles/600183

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References (8)

  1. Abdelmageed MI, Abdelmoneim AH, Mustafa MI, Elfadol NM, Murshed NS et al. (2020). Design of a multiepitope-based peptide vaccine against the E protein of human COVID-19: An immunoinformatics approach. BioMed Research International doi: 10.1101/2020.02.04.934232 Acar T, Arayıcı PP, Ucar B, Karahan M, Mustafaeva Z (2019). Synthesis, characterization and lipophilicity study of Brucella abortus’ immunogenic peptide sequence that can be used in the future vaccination studies. International Journal of Peptide Research and Therapeutics 25: 911-918.
  2. Ahmed SF, Quadeer AA, McKay MR (2020). Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies. Viruses 12: 254. Ali M, Pandey RK, Khatoon N, Narula A, Mishra A et al. (2017). Exploring dengue genome to construct a multi-epitope based subunit vaccine by utilizing immunoinformatics approach to battle against dengue infection. Scientific Reports 7: 1-13.
  3. Almofti YA, Abd-elrahman KA, Gassmallah SAE, Salih MA (2018). Multi epitopes vaccine prediction against severe acute respiratory syndrome (SARS) coronavirus using immunoinformatics approaches. American Journal of Microbiological Research 6: 94-114.
  4. Amanat F, Krammer F (2020). SARS-CoV-2 vaccines: Status report. Immunity 52 (4): 583-589. doi: 10.1016/j.immuni.2020.03.007 Bahrami AA, Payandeh Z, Khalili S, Zakeri A, Bandehpour M (2019). Immunoinformatics: In silico approaches and computational design of a multi-epitope, immunogenic protein. International Reviews of Immunology 38: 307-322.
  5. Baruah V, Bose S (2020). Immunoinformatics‐aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019‐ nCoV. Journal of Medical Virology 92: 495-500.
  6. Behrendt R, White P, Offer J (2016). Advances in Fmoc solid-phase peptide synthesis. Journal of Peptide Science 22: 4-27.
  7. Bhattacharya M, Ranjan Sharma A, Patra P, Ghosh P, Sharma G et al. (2020). Development of epitope-based peptide vaccine against novel Coronavirus 2019 (SARS-COV-2): Immunoinformatics approach. Journal of Medical Virology 92 (6). doi: 10.1002/ jmv.25736 Biswas S, Chatterjee S, Dey T, Dey S, Manna S et al. (2020). In silico approach for peptide vaccine design for CoVID 19. MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition session, USINEWS-04: US-IN-EU Worldwide Science Workshop Series, UMN, Duluth, USA, 2020.
  8. Bojin F, Gavriliuc O, Margineanu M-B, Paunescu V (2020). Design of an epitop