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Journals / Turkish Journal of Biology / 2022 / Cilt: 46 - Sayı: 3

Design and in vitro, in vivo evaluation of antioxidant bioadhesive gels for burn treatment

Çetin PEKÇETİN
Evren ALGIN YAPAR
Göksel GÖKÇE
Alper BAĞRIYANIK
Sinem Yaprak KARAVANA
Gülşen AYBAR TURAL
Evren Homan GÖKÇE
Pages
251–262
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, bio-adhesive CP 940 (2%) gel containing 50 mM taurine could be promising in the treatment of burns by balancing oxidative stress.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance.
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Key Findings & Data:Antioxidant taurine containing bio-adhesive gels were prepared by using carbopol (CP) 940 and 934.
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Conclusion & Impact:In conclusion, bio-adhesive CP 940 (2%) gel containing 50 mM taurine could be promising in the treatment of burns by balancing oxidative stress.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance. Availability of use of antioxidant agents and bio-adhesive gels in tissue healing can be an alternative as a new approach for wound healing. Antioxidant taurine containing bio-adhesive gels were prepared by using carbopol (CP) 940 and 934. Rheological and texture analyses were carried out on bio-adhesive gels for in vitro characterization. Wound model on Wistar rats was used to evaluate the in vivo evaluation of gels. Rheological and texture analyses showed that a carbopol bioadhesive gel has acceptable topically use dosage characteristics and in combination with Taurine it presented a successful wound healing effect via antioxidant parameters. In conclusion, bio-adhesive CP 940 (2%) gel containing 50 mM taurine could be promising in the treatment of burns by balancing oxidative stress.

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Cite This Article

PEKÇETİN, Ç., YAPAR, E. A., GÖKÇE, G., BAĞRIYANIK, A., KARAVANA, S. Y., TURAL, G. A., GÖKÇE, E. H. (2022). Design and in vitro, in vivo evaluation of antioxidant bioadhesive gels for burn treatment. Turkish Journal of Biology, Cilt: 46 - Sayı: 3, 251–262. https://ajindex.com/articles/600090

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