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Journals / The Turkish Journal of Ear Nose and Throat / 2018 / Cilt: 28 - Sayı: 2

Thiol-disulphide homeostasis in chronic sinusitis without polyposis

Mehmet Hakan KORKMAZ
Özcan EREL
Kazım BOZDEMİR
Arife SEZGİN
Ahmet AKKOZ
Pages
66–70
Publication Date
2022-10-19
DOI
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Chronic sinusitis patients hadsignificantly lower native and thiol value than control group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Oxidative stress plays a role in the pathogenesis of chronic mucosal inflammation in chronic sinusitis and we aimed toinvestigate a novel oxidative stress marker, thiol/disulphide homeostasis.Patients and Methods: A total of 60 subjects (30 chronic sinusitis patients and 30 healthy volunteers) were included in the study.Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu.Results: The average native thiol value of the chronic sinusitis group was 475.6 µmol/L and 515.8 µmol/L in the control group.The total thiol was 509.4 and 552.2 µmol/L respectively for the chronic sinusitis and control groups.
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Key Findings & Data:Objectives: Oxidative stress plays a role in the pathogenesis of chronic mucosal inflammation in chronic sinusitis and we aimed toinvestigate a novel oxidative stress marker, thiol/disulphide homeostasis.Patients and Methods: A total of 60 subjects (30 chronic sinusitis patients and 30 healthy volunteers) were included in the study.Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu.Results: The average native thiol value of the chronic sinusitis group was 475.6 µmol/L and 515.8 µmol/L in the control group.The total thiol was 509.4 and 552.2 µmol/L respectively for the chronic sinusitis and control groups.
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Conclusion & Impact:Chronic sinusitis patients hadsignificantly lower native and thiol value than control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Oxidative stress plays a role in the pathogenesis of chronic mucosal inflammation in chronic sinusitis and we aimed toinvestigate a novel oxidative stress marker, thiol/disulphide homeostasis.Patients and Methods: A total of 60 subjects (30 chronic sinusitis patients and 30 healthy volunteers) were included in the study.Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu.Results: The average native thiol value of the chronic sinusitis group was 475.6 µmol/L and 515.8 µmol/L in the control group.The total thiol was 509.4 and 552.2 µmol/L respectively for the chronic sinusitis and control groups. Chronic sinusitis patients hadsignificantly lower native and thiol value than control group (p

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Cite This Article

KORKMAZ, M. H., EREL, Ö., BOZDEMİR, K., SEZGİN, A., AKKOZ, A. (2022). Thiol-disulphide homeostasis in chronic sinusitis without polyposis. The Turkish Journal of Ear Nose and Throat, Cilt: 28 - Sayı: 2, 66–70. https://ajindex.com/articles/597950

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